1-Acetyl-4-piperidinecarboxylic acid

CAS No.：25503-90-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1-Acetyl-4-piperidinecarboxylic acid Basic information

Product Name:	1-Acetyl-4-piperidinecarboxylic acid
Synonyms:	4-Piperidinecarboxylic acid, 1-acetyl-;RARECHEM AL BO 0864;N-ACETYLISONIPECOTIC ACID;TIMTEC-BB SBB000171;1-Acetylpiperidine-4-CarboxylicAcid/N-AcetylisonipecoticAcid;1-Acetylpiperidine-4-carboxylic acid, 95+%;1-Acetyl-4-piperidine;ac-dl-inp-oh
CAS:	25503-90-6
MF:	C8H13NO3
MW:	171.19
EINECS:	247-049-6
Product Categories:	Building Blocks;C8;Heterocycles;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines;Piperidines, Piperidones, Piperazines;Pyridine series;PiperidineDerivative;API intermediates;Heterocyclic Compounds;Neurochemicals;Carboxylic Acids;Pyrans, Piperidines & Piperazines
Mol File:	25503-90-6.mol

1-Acetyl-4-piperidinecarboxylic acid Chemical Properties

Melting point	180-184 °C (lit.)
Boiling point	301.17°C (rough estimate)
density	1.1998 (rough estimate)
refractive index	1.4750 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Methanol (Slightly), Water (Slightly)
pka	4.35±0.20(Predicted)
form	Crystalline Powder
color	White to beige
Water Solubility	50 g/L (20 ºC)
BRN	389577
CAS DataBase Reference	25503-90-6(CAS DataBase Reference)
NIST Chemistry Reference	1-Acetyl-4-piperidinecarboxylic acid(25503-90-6)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38-43
Safety Statements	26-36-37/39
WGK Germany	2
HazardClass	IRRITANT
HS Code	29339900

MSDS Information

Provider	Language
1-Acetylpiperidine-4-carboxylic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

1-Acetyl-4-piperidinecarboxylic acid Usage And Synthesis

Chemical Properties	White Crystalline Solid
Uses	A synthetic intermediate in the preparation of CNS depressants
Uses	Reactant for synthesis of:• ;Triazole derivatives1• ;Antiproliferative agents2• ;CDK inhibitors3• ;CCR5 antagonists for HIV treatment4• ;nhNK1 antagonists5• ;Piperidine derivatives6
Uses	Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene.

1-Acetyl-4-piperidinecarboxylic acid Preparation Products And Raw materials

Raw materials	Acetic anhydride-->Isopropyl alcohol-->Diisopropyl ether-->Isonipecotic acid
Preparation Products	1-[4-(2,4-DIFLUORO-BENZOYL)-PIPERIDIN-1-YL]-ETHANONE-->4-BENZOYLPIPERIDINE HYDROCHLORIDE-->4-BENZOYLPIPERIDINE HYDROCHLORIDE

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