1,1'-(Azodicarbonyl)-dipiperidine

CAS No.：10465-81-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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1,1'-(Azodicarbonyl)-dipiperidine Basic information

Product Name:	1,1'-(Azodicarbonyl)-dipiperidine
Synonyms:	Diphenylpiperidylcarboxylate;AZODICARBOXYLIC ACID DIPIPERIDYL ESTER;Azodicarboxylic;diazenedicarboxylic acid bis(N,N-piperidide);1,1-IAZODICARBONYL)DIPIPERIDINE;Azodicarboxylic acid dipiperidine,95%;1,1'-(Azodicarbonyl);1,1'-(Azodicarbonyl)dipiperidine(ADDP)
CAS:	10465-81-3
MF:	C12H20N4O2
MW:	252.31
EINECS:
Product Categories:	API intermediates;Azodicarboxylates & Amides;Mitsunobu Reaction;Synthetic Organic Chemistry
Mol File:	10465-81-3.mol

1,1'-(Azodicarbonyl)-dipiperidine Chemical Properties

Melting point	132-136 °C(lit.)
Boiling point	366.4±25.0 °C(Predicted)
density	1.29±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	-0?+-.0.20(Predicted)
form	solid
color	yellow
Water Solubility	Slightly soluble in water.
BRN	261917
CAS DataBase Reference	10465-81-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	3234
WGK Germany	3
TSCA	No
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English

1,1'-(Azodicarbonyl)-dipiperidine Usage And Synthesis

Description	1,1''-(Azodicarbonyl)dipiperidine (ADDP) is a reagent commonly used in the Mitsunobu reaction for the condensation of an alcohol and an acidic compound. It has been used as a reagent in the synthesis of G protein-coupled receptor 120 (GPR120) agonists with antidiabetic activity and peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ triple agonists.
Chemical Properties	yellow crystalline powder
Uses	It is used in a study of the copper-catalyzed addition of aryboronic acids to azodicarboxyl derivatives providing aryl-substituted hydrazides. It is widely used reagent for the Mitsunobu reaction. It is reactant for preparation of polyfluoroalkylated tripyrazolylmethane ligands, (-)-Hygromycin A via Mitsunobu glycosylation, optically active α,α-disubstituted amino acids via Mitsunobu reaction, aza-β-lactams through [2+2] cycloaddition reactions, glycosyl disulfides, pyridine ether PPAR agonists, S-glycosyl amino acid, building blocks for combinatorial neoglycopeptide synthesis and is a histamine H3 receptor antagonists. It is a reactant for Mitsunobu inversion reactions.

1,1'-(Azodicarbonyl)-dipiperidine Preparation Products And Raw materials

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