Tetrahydrothiophen-3-one

CAS No.：1003-04-9

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

Tetrahydrothiophen-3-one Basic information

Product Name:	Tetrahydrothiophen-3-one
Synonyms:	3-Oxotetrahydrothiophene;3-Thiacyclopentanone;dihydro-3(2h)-thiophenon;Dihydro-3-Thiophenone;Thiolan-3-one;4,5-DIHYDRO-3(2H)-THIOPHENONE;3-THIOPHANONE;dihydrothiophen-3(2h)-one
CAS:	1003-04-9
MF:	C4H6OS
MW:	102.15
EINECS:	213-698-9
Product Categories:	Thiophene&Benzothiophene;thiophene Flavor;Thiophen flavors
Mol File:	1003-04-9.mol

Tetrahydrothiophen-3-one Chemical Properties

Boiling point	175 °C(lit.)
density	1.194 g/mL at 25 °C(lit.)
vapor density	>1 (vs air)
refractive index	n20/D 1.528(lit.)
FEMA	3266 \| 4,5-DIHYDRO-3(2H)THIOPHENONE
Fp	171 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Liquid
Specific Gravity	1.194
color	Colorless to pale yellow
JECFA Number	498
BRN	105201
CAS DataBase Reference	1003-04-9(CAS DataBase Reference)
NIST Chemistry Reference	Dihydro-3-(2H)-thiophenone(1003-04-9)
EPA Substance Registry System	3(2H)-Thiophenone, dihydro- (1003-04-9)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-36/37/39
RIDADR	UN 3334
WGK Germany	3
F	8-13
Hazard Note	Irritant
TSCA	Yes
HS Code	29349990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Tetrahydrothiophen-3-one Usage And Synthesis

Description	Tetrahydro-thiophene-3-one is a heterocyclic nonaromatic ketone. It has a garlic meaty, green vegetable, buttery odor. It is present in cooked beef, coffee, roast filbert, and roasted peanut. Tetrahydro-thiophene-3-one is used as a food flavoring agent. It is also a valuable organic substance key that opens the synthetic access to numerous derivatives of thiophene.
Chemical Properties	4,5-Dihydro-3-(2H)thiophenone has a garlic meaty, green vegetable, buttery odor. It is a heterocyclic nonaromatic ketone.
Chemical Properties	Clear light yellow liquid
Occurrence	Reported found in cooked beef, coffee, roasted filberts and roasted peanuts.
Uses	4,5-Dihydro-3(2H)-thiophenone is a volatile organic sulfur compound (VOSC) produced by basidiomycetous yeasts.
Uses	Used for blending soft drinks, beverage, meat products, confectionery, and milk product flavors.
Preparation	From 4-methoxycarboxyl-3-oxothiophane treated with 10% sulfuric acid.
Taste threshold values	Taste characteristics at 15 ppm: onion, garlic, cooked meaty with vegetables nuances
Synthesis Reference(s)	Journal of the American Chemical Society, 68, p. 2229, 1946 DOI: 10.1021/ja01215a034
References	[1] George A. Burdock (2010) Fenaroli's Handbook of Flavor Ingredients, Sixth Edition [2] https://pubchem.ncbi.nlm.nih.gov [3] Patent 0127121 A1: Process for the preparation of tetrahydro-thiophen-3-one

Tetrahydrothiophen-3-one Preparation Products And Raw materials

Raw materials

BENZHYDRYL ACETATE-->TETRAHYDRO-THIOPHEN-3-OL-->danosteine-->METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873