Product

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

CAS No.：88546-55-8

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OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Basic information

Product Name:	OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
Synonyms:	Esomeprazole sodium D(H168/66);Esomeprazole Sodium?CP Impurity Ⅰ;5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfonyl]benzimidazole;EsoMeprazol iMpurity D;OMeprazole IMpurity-D(EP) (USP R C A);6-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfonyl)-1H-benzo[d]iMidazole;OMeprazole EP IMpurity D;5-Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl]-1H-benziMidazole
CAS:	88546-55-8
MF:	C17H19N3O4S
MW:	361.42
EINECS:
Product Categories:	Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Isotopically Labeled Pharmaceutical Reference Standard;Acid pump inhibitors
Mol File:	88546-55-8.mol

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Chemical Properties

Melting point	80-82°C
Boiling point	599.3±60.0 °C(Predicted)
density	1.331±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	≥40.6 mg/mL in DMSO,≥19.9 mg/mL in EtOH,insoluble in H2O
pka	7.97±0.10(Predicted)
form	neat
BRN	8347309

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	2
HS Code	29333990

MSDS Information

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Usage And Synthesis

Description	Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole and is found in plasma. Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC₅₀ = 18 μM).
Chemical Properties	Light Yellow Solid
Uses	A metabolite of Omeprazole.
Uses	A metabolite of Omeprazole
in vitro	omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of cyp2c19 in pooled human liver microsomes with an ic50 of 18 μm [1].
in vivo	three hours after intake of 20 mg omeprazole only, the geometric mean plasma concentration of omeprazole sulfone were 106 nmol/l in 22 samples from subjects known to be extensive cyp2c19 metabolizers (em) and 672 nmol/l in the five subjects known to be poor cyp2c19 metabolizers (pm). the mean log10(omeprazole/omeprazole sulfone) ratio was 0.18 [4].
references	[1] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.[2] bel a, andersson t b, antonsson m, et al. stereoselective metabolism of omeprazole by human cytochrome p450 enzymes[j]. drug metabolism and disposition, 2000, 28(8): 966-972.[3] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.[4] bttiger y. use of omeprazole sulfone in a single plasma sample as a probe for cyp3a4[j]. european journal of clinical pharmacology, 2006, 62(8): 621-625.

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Preparation Products And Raw materials

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