(R)-(-)-1-Phenyl-1,2-ethanediol

CAS No.：16355-00-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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(R)-(-)-1-Phenyl-1,2-ethanediol Basic information

Product Name:	(R)-(-)-1-Phenyl-1,2-ethanediol
Synonyms:	(R)-(-)-1-Phenyl-1,2-ethanediol 99%;(R)-1-Phenyl-1,2-ethanediol,99%e.e.;(1R)-(-)-1-PHENYL-1,2-ETHANEDIOL;(R)-(-)-PHENYL-1,2-ETHANEDIOL;R(-)-PHENYLETHYLENE GLYCOL;(R)-(-)-STRYRENE GLYCOL;(R)-(-)-STYRENEGLYCOL;(R)-STYRENE GLYCOL
CAS:	16355-00-3
MF:	C8H10O2
MW:	138.16
EINECS:	202-258-1
Product Categories:	fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis, functional materials;Aromatics;Chiral Building Blocks;Simple Alcohols (Chiral);Chiral Reagents;Intermediates;Chiral Compounds;Diols;chiral;Synthetic Organic Chemistry
Mol File:	16355-00-3.mol

(R)-(-)-1-Phenyl-1,2-ethanediol Chemical Properties

Melting point	64-67 °C(lit.)
alpha	-69 º (c=1, chloroform)
Boiling point	272-274 °C(lit.)
density	1.0742 (rough estimate)
refractive index	-40 ° (C=3, H2O)
Fp	272-274°C
storage temp.	2-8°C
solubility	Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
pka	13.61±0.20(Predicted)
form	Solid
color	Off-White
optical activity	[α]20/D 69°, c = 1 in chloroform
Water Solubility	SOLUBLE
Merck	14,8861
BRN	2355547
CAS DataBase Reference	16355-00-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,T
Risk Statements	23/24/25-36/37/38
Safety Statements	24/25-45-36/37/39-26
WGK Germany	3
Hazard Note	Irritant
HS Code	29062900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

(R)-(-)-1-Phenyl-1,2-ethanediol Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	(R)-(-)-1-Phenyl-1,2-ethanediol is an intermediate for the synthesis of enantiopure substituted 1,4-Dioxanes. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis.
Uses	Intermediate for the synthesis of chiral phosphine catalysts for asymmetric hydrogenations.
Purification Methods	Purify the diol by recrystallisation from *C6H6/ligroin and sublime it at 1-2mm. [Arpesella et al. Gazetta 85 1354 1955, Prelog et al. Helv Chim Acta 37 221 1954, Beilstein 6 IV 5939.]

(R)-(-)-1-Phenyl-1,2-ethanediol Preparation Products And Raw materials

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