4-Chlorobenzoyl chloride

CAS No.：122-01-0

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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4-Chlorobenzoyl chloride Basic information

Uses

Product Name:	4-Chlorobenzoyl chloride
Synonyms:	LABOTEST-BB LTBB000569;4-Chlorobenzoyl chloride, 99+% 5ML;4-CHLOROBENZOYL CHLORIDE FOR SYNTHESIS;Chlorobenzene forMyl chloride;4-chloro-benzoylchlorid;Benzoyl chloride, 4-chloro-;Benzoyl chloride, p-chloro-;Benzoylchloride,4-chloro-
CAS:	122-01-0
MF:	C7H4Cl2O
MW:	175.01
EINECS:	204-515-3
Product Categories:	ACIDHALIDE;Absolute Configuration Determination (Exciton Chirality CD Method);Analytical Chemistry;Enantiomer Excess & Absolute Configuration Determination;Exciton Chirality CD Method (for Hydroxyl Groups);Acid Halides;Carbonyl Compounds;Organic Building Blocks;Absolute Configuration Determination
Mol File:	122-01-0.mol

4-Chlorobenzoyl chloride Chemical Properties

Melting point	11-14 °C (lit.)
Boiling point	102-104 °C/11 mmHg (lit.)
density	1.365 g/mL at 20 °C (lit.)
vapor pressure	5.8-73.9Pa at 20-50℃
refractive index	n20/D 1.578(lit.)
Fp	221 °F
storage temp.	Store below +30°C.
form	Liquid
color	Clear colorless to faintly colored
explosive limit	1.5-15%(V)
Water Solubility	Reacts with water. Reacts with alcohol.
FreezingPoint	12~14℃
Sensitive	Moisture Sensitive
BRN	471606
Stability:	Stable. Moisture sensitive. Incompatible with strong oxidizing agents.
LogP	2.52 at 25℃
CAS DataBase Reference	122-01-0(CAS DataBase Reference)
NIST Chemistry Reference	4-Chlorobenzoic acid chloride(122-01-0)
EPA Substance Registry System	Benzoyl chloride, 4-chloro- (122-01-0)

Safety Information

Hazard Codes	C
Risk Statements	34-36/37
Safety Statements	26-36/37/39-45-28A
RIDADR	UN 3265 8/PG 2
WGK Germany	1
RTECS	DM6635510
F	10-19-21
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29163900

MSDS Information

Provider	Language
4-Chlorobenzoyl chloride	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Chlorobenzoyl chloride Usage And Synthesis

Uses	4-Chlorobenzoyl Chloride is used as a promoter in the synthesis of α-aminonitriles. It is also used as a derivatization agent and self-assembling dipole molecule to improve hole injection in conjugated polymers. In addition. It is an important organic intermediate to synthetize substituted 4-chlorobenzoyl products.
Chemical Properties	liquid
Uses	4-Chlorobenzoyl chloride was used to synthesize 4-chlorobenzoyl CoA by reacting it with CoA in KHCO3 buffer. 4-Chlorobenzoyl chloride may be used in the following studies Acylation of benzene using different solid acid catalysts such as dodecatungstophosphoric acid (DTPA), DTPA/K-10 clay, K-10, Amberlite, Amberlyst-15, Indion-130, Filtrol-24 clay and sulfated zirconia, Preparation of 1-(4-chlorobenzoyl)-2, 7-dimethoxynaphthalene, Preparation of 4-chlorobenzoyl CoA, via reaction with CoA in KHCO3 buffer, Preparation of 1-aryloxyacetyl-4-(4-chlorobenzoyl)-semicarbazides.
Uses	4-Chlorobenzoyl chloride was used to synthesize 4-chlorobenzoyl CoA by reacting it with CoA in KHCO3 buffer.
Definition	ChEBI: An acyl chloride consisting of benzoyl chloride having a chloro substituent in the para-position.
General Description	4-Chlorobenzoyl chloride is an acyl chloride. It reacts with 2-amino-2-seleno-5,5-dimethyl-1,3,2-dioxaphosphorinane to yield the respective N-acyl selenophosphoramides.

4-Chlorobenzoyl chloride Preparation Products And Raw materials

Raw materials

Thionyl chloride-->4-Chlorobenzoic acid

Preparation Products

Moclobemide-->Rebamipide-->3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2，2-dimethyl cyclopropane carboxylic acid-->4-chloro-1'-(4-methoxyphenyl)benzohydrazide-->Indometacin-->4-Chlorobenzophenone-->4-Chloro-4'-hydroxybenzophenone-->4-chloro-4'-methoxybenzophenone-->Fenofibrate-->4-Chloro-3',4'-dimethoxybenzophenone-->4,4'-Dichlorobenzophenone-->4-Chloro-alpha-methylstyrene-->Benzenecarbothioic acid, 4-chloro-, anhydrosulfide with thiocyanic acid-->2-chloro-4-(4-chlorophenyl)-6-phenyl-1,3,5-triazine-->4-CHLOROBENZOYLACETONITRILE-->4-CHLOROBENZOYL ISOTHIOCYANATE-->4-chloro-N-(7-oxo-7H-benzo[e]perimidin-6-yl)benzamide

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