Other grades of this product :
| N-Methyl-D-aspartic acid Basic information |
| N-Methyl-D-aspartic acid Chemical Properties |
| Melting point | 187-192 °C | | alpha | -28 º (c=1, HCl 6N) | | Boiling point | 267.21°C (rough estimate) | | density | 1.4285 (rough estimate) | | refractive index | -15 ° (C=2, H2O) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly) | | pka | 2.21±0.23(Predicted) | | form | solid | | color | white | | Water Solubility | slightly soluble | | Sensitive | Hygroscopic | | Merck | 14,6662 | | BRN | 1724431 | | CAS DataBase Reference | 6384-92-5(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | CI9457000 | | F | 10 | | HS Code | 29225090 |
| N-Methyl-D-aspartic acid Usage And Synthesis |
| Chemical Properties | white to off-white crystalline powder | | Uses | NMDA agonist | | Uses | NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. | | Definition | ChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration. | | General Description | N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase. | | Biological Activity | Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™ . | | Biochem/physiol Actions | Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy. | | references | [1] watkins jc, jane de. the glutamate story. br j pharmacol. 2006 jan;147 suppl 1:s100-8.[2] lafon-cazal m, pietri s, culcasi m, bockaert j. nmda-dependent superoxide production and neurotoxicity. nature. 1993 aug 5;364(6437):535-7. |
| N-Methyl-D-aspartic acid Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye