Ethyl malonyl chloride

Ethyl malonyl chloride
  • CAS No.:36239-09-5

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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Ethyl malonyl chloride Basic information
Product Name:Ethyl malonyl chloride
Synonyms:Acetic acid, (chloroformyl)-, ethyl ester;Carbethoxyethanoyl chloride;Ethyl 3-oxo-3-chloropropanoate;Ethyl malonyl chloride, 90%, tech.;3-Oxo-3-chloropropanoic acid ethyl ester;3-Oxo-3-chloropropionic acid ethyl ester;2-(chlorocarbonyl)butanoic acid;Ethyl malonyl chloride,Ethyl (chloroformyl)acetate, Ethyl 3-chloro-3-oxopropionate
CAS:36239-09-5
MF:C5H7ClO3
MW:150.56
EINECS:252-934-5
Product Categories:Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Pharmaceutical raw material;Aliphatics;Pharmaceutical intermdiate
Mol File:36239-09-5.mol
Ethyl malonyl chloride Chemical Properties
Boiling point 79-80 °C25 mm Hg(lit.)
density 1.196 g/mL at 20 °C
refractive index n20/D 1.429(lit.)
Fp 154 °F
storage temp. 2-8°C
form Liquid
pka9.35±0.46(Predicted)
Specific Gravity1.176
color Clear yellow to brown
Water Solubility REACTS
Sensitive Moisture Sensitive
BRN 636215
CAS DataBase Reference36239-09-5(CAS DataBase Reference)
NIST Chemistry ReferenceEthyl malonyl chloride(36239-09-5)
Safety Information
Hazard Codes C
Risk Statements 14-34
Safety Statements 7-26-36/37/39-45-36/39
RIDADR UN 3265 8/PG 3
WGK Germany 3
F 10-21
Hazard Note Corrosive
HazardClass 8
PackingGroup II
HS Code 29171900
MSDS Information
ProviderLanguage
Ethyl (chloroformyl)acetate English
SigmaAldrich English
ACROS English
ALFA English
Ethyl malonyl chloride Usage And Synthesis
Chemical Propertiesclear yellow to brown liquid
UsesEmployed in the synthesis of 3-pyrrolin-2-ones via amidation with propargylamines and subsequent base catalyzed 5-exo-dig cyclization.1
UsesEthyl malonyl chloride is used in the syntheses of methanofullerodendimers and 3-pyrrolin-2-ones. It plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks. It is a versatile acylating agent for propargyl alcohols, hydrazines and amines.
General DescriptionEthyl malonyl chloride is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

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