Product

6-O-Benzylguanine

CAS No.：19916-73-5

Other grades of this product :

6-O-Benzylguanine Basic information

Product Name:	6-O-Benzylguanine
Synonyms:	O(sup 6)benzylguanidine;O6-Benzylguanine ,98%;2-Amino-6-(benzyloxy)-9H-purine;6-(Benzyloxy)-1H-purin-2-amine;6-(benzyloxy)-7H-purin-2-aMine;6-(PhenylMethoxy)-9H-purin-2-aMine;NSC 637037;6-benzylguanine
CAS:	19916-73-5
MF:	C12H11N5O
MW:	241.25
EINECS:	1592732-453-0
Product Categories:	Alkylguanine-DNA alkyltransferase, mammalian DNA repair proteinApoptosis and Cell Cycle;DNA Repair Regulators;Nucleotides and Nucleosides;A to;DNA metabolism;Enzyme Inhibitors by Enzyme;Bases & Related Reagents;Nucleotides
Mol File:	19916-73-5.mol

6-O-Benzylguanine Chemical Properties

Melting point	193(dec.)
Boiling point	459.3±55.0 °C(Predicted)
density	1.48±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	methanol: 20 mg/mL
form	solid
pka	7.47±0.20(Predicted)
color	Off-White to Light Yellow
CAS DataBase Reference	19916-73-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
Hazard Note	Irritant
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English

6-O-Benzylguanine Usage And Synthesis

Chemical Properties	Light Yellow Solid
Uses	An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.
Uses	O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Biochem/physiol Actions	O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.

6-O-Benzylguanine Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Acetic acid-->N,N-Dimethylformamide-->Toluene-->Phosphorus oxychloride-->Acetonitrile-->Activated carbon-->1,2-Dichloroethane-->Benzyl alcohol-->6-Chloroguanine-->Guanine-->Tetraethylammonium Chloride

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