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| 3-Chloropropiophenone Basic information |
| 3-Chloropropiophenone Chemical Properties |
| Melting point | 48-50 °C(lit.) | | Boiling point | 113-115 °C4 mm Hg(lit.) | | density | 1.1115 (rough estimate) | | refractive index | 1.5350 (estimate) | | Fp | >230 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | Off-White to Pale Yellow | | Water Solubility | Insoluble | | BRN | 2043580 | | Stability: | Stable. Incompatible with strong bases, strong oxidizing agents. | | CAS DataBase Reference | 936-59-4(CAS DataBase Reference) | | NIST Chemistry Reference | 1-Propanone, 3-chloro-1-phenyl-(936-59-4) | | EPA Substance Registry System | 1-Propanone, 3-chloro-1-phenyl- (936-59-4) |
| 3-Chloropropiophenone Usage And Synthesis |
| Description | 3-Chloropropiophenone is a chiral compound that is used as an antidepressant drug. It was first synthesized in the 1950s and has been studied extensively for its pharmacological effects. It is a racemic mixture of two enantiomers, one of which is active and the other inactive. The active enantiomer binds to serotonin receptors and inhibits the reuptake of serotonin, which leads to an increase in serotonin levels. The inactive enantiomer does not bind to serotonin receptors and does not inhibit the reuptake of serotonin. 3-Chloropropiophenone has been shown to be effective when administered at an optimum concentration of 5 milligrams per kilogram body weight. | | Chemical Properties | faintly yellow to tan crystalline powder | | Uses | 3-Chloropropiophenone is an Impurity of Fluoxetine (F597100). | | Uses | 3-Chloropropiophenone was used in the asymmetric reduction of (S)-3-chloro-1-phenylpropanol using preheated Candida utilis cells immobilized in calcium alginate gel beads. It was also used in the synthesis of (R)-3-chloro-1-phenyl-1-propanol via asymmetric reduction using in-situ generated oxazaborolidine catalyst derived from (S)-α,α-diphenylprolinol. It is a precursor of phenyl vinyl ketone. |
| 3-Chloropropiophenone Preparation Products And Raw materials |
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