1-Boc-4-cyanopiperidine

CAS No.：91419-52-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1-Boc-4-cyanopiperidine Basic information

Product Name:	1-Boc-4-cyanopiperidine
Synonyms:	1-Piperidinecarboxylic acid, 4-cyano-, 1,1-dimethylethyl ester;Boc-4-cyanopiperidine;1-BOC-PIPERIDINE-4-CARBONITRILE;N-Boc-piperidine-4-carbonitrile;N-boc-4-cyanopiperidie;1-Boc-4-cyanopiperid;N-tert-Butoxycarbonyl-4-cyanopiperidine;1-N-Boc-4-cyano-piperidine ,98%
CAS:	91419-52-2
MF:	C11H18N2O2
MW:	210.27
EINECS:
Product Categories:	Heterocyclic Building Blocks;pharmacetical;Pyrans, Piperidines &Piperazines;Piperidine;Piperazine;Aromatics;Boron, Nitrile, Thio,& TM-Cpds;Heterocycles;Pyrans, Piperidines & Piperazines
Mol File:	91419-52-2.mol

1-Boc-4-cyanopiperidine Chemical Properties

Melting point	60-63 °C
Boiling point	325.3±35.0 °C(Predicted)
density	1.07±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform
form	Crystalline Powder
pka	-3.08±0.40(Predicted)
color	White to off-white
CAS DataBase Reference	91419-52-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,N
Risk Statements	20/21/22-50-36-22
Safety Statements	36-36/37/39-61-26
RIDADR	3439
WGK Germany	3
Hazard Note	Harmful
HazardClass	6.1
PackingGroup	III
HS Code	29333990

MSDS Information

1-Boc-4-cyanopiperidine Usage And Synthesis

Chemical Properties	Yellowish Oil
Uses	Reactant for synthesis of: Aminomethylated fluoropiperidines Protein kinase B inhibitors GlyT1 inhibitors Piperidinecarboxylic acids via nitrilase-catalyzed enantioselective synthesis Reactant for Replacement in CB2 receptor inhibitors Double addition reactions of methyllithium and n-butyllithium to unsaturated nitriles

1-Boc-4-cyanopiperidine Preparation Products And Raw materials

Raw materials

Thionyl chloride-->Phosphorus oxychloride-->Chloroform-->Ammonium hydroxide-->Di-tert-butyl dicarbonate-->Isonipecotic acid-->Hexahydroisonicotinamide-->1-Boc-4-methanesulfonyloxypiperidine-->1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde-->N-BOC-piperidine-4-carboxylic acid-->4-(METHYLSULFONYL)BENZONITRILE-->1-PIPERIDINECARBOXYLIC ACID,4-[(HYDROXYIMINO)METHYL]-,1,1-DIMETHYLETHYL ESTER-->TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE-->1-N-BOC-4-BROMOPIPERIDINE-->N-BOC-4-Hydroxypiperidine-->4-Cyanopiperidine-->Tosyl cyanide

Preparation Products

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate

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