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| 4'-(Trifluoromethyl)acetophenone Basic information | | Synthesis |
| 4'-(Trifluoromethyl)acetophenone Chemical Properties |
| Melting point | 30-33 °C(lit.) | | Boiling point | 79-80 °C8 mm Hg(lit.) | | density | 0.92 | | refractive index | 1.4604 | | Fp | 184 °F | | storage temp. | Sealed in dry,Room Temperature | | form | Low Melting Solid | | color | White to faintly yellow | | BRN | 1870425 | | CAS DataBase Reference | 709-63-7(CAS DataBase Reference) | | NIST Chemistry Reference | 4-CF3-C6H4-COCH3(709-63-7) |
| 4'-(Trifluoromethyl)acetophenone Usage And Synthesis |
| Synthesis | 41.6 g of chlorocyclohexane (0.35 mol) were added dropwise to a suspension of 4.65 g of lithium particles (0.68 mol) in 350 g of THF at -55 °C, and an addition time of 2 hours was chosen. After >97% chlorocyclohexane conversion by GC (10 hours), a mixture of 38.3 g of 4-bromotrifluorotoluene (0.170 mol) and 7.0 g of acetonitrile (0.170 mol) was added dropwise at the same temperature for 15 minutes. After stirring for an additional 30 minutes at -50°C, the reaction mixture was slowly thawed to room temperature and subjected to an aqueous workup in a conventional manner. The yield of 4-trifluoromethylacetophenone after distillation was 81%. | | Chemical Properties | White to faintly yellow low melting solid | | Uses | A labelled acetophenone with selective antimycobacterial activity. | | General Description | The enantioselective addition of dialkylzinc to 4′-(trifluoromethyl)acetophenone mediated by 1,2-bis(hydroxycamphorsulfonamido)cyclohexenes in the presence of titanium tetraisopropoxide has been investigated. Phosphorescence emission spectra of 4′-(trifluoromethyl)acetophenone has been studied using pulsed source phosphorimetry. | | Purification Methods | Purify the ketone by distillation or sublimation in vacuo.[Beilstein 7 IV 1404.] |
| 4'-(Trifluoromethyl)acetophenone Preparation Products And Raw materials |
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