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| (R)-MOP Basic information |
| Product Name: | (R)-MOP | | Synonyms: | R-MOP >=94%;[(R)-2'-Methoxy[1,1'-binaphthalen]-2-yl]diphenylphosphine,99%e.e.;(R)-(+)-2-DIPHENYLPHOSPHINO-2'-METHOXY-1,1'-BINAPHTHYL;(S)-(-)-(DIPHENYLPHOSPHINO)-2'-METHOXY-1,1'-BINAPHTHYL;(R)-(+)-MOP;(R)-MOP;(S)-(-)-2-(DIPHENYLPHOSPHINO)-2'-METHOXY-1,1'-BINAPHTHYL;(S)-2-(DIPHENYLPHOSPHINO)-2'-METHOXY-1,1'-BINAPHTHYL | | CAS: | 145964-33-6 | | MF: | C33H25OP | | MW: | 468.52 | | EINECS: | | Product Categories: | Chiral Phosphine;API intermediates;Chiral Reagents | | Mol File: | 145964-33-6.mol |
| (R)-MOP Chemical Properties |
| Melting point | 177-179°C | | alpha | +67° ±2° (c 1, toluene) | | Boiling point | 584.1±38.0 °C(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | almost transparency in Toluene | | form | Powder | | color | white | | optical activity | [α]20/D +94°, c = 0.5 in chloroform | | Sensitive | air sensitive | | CAS DataBase Reference | 145964-33-6(CAS DataBase Reference) |
| (R)-MOP Usage And Synthesis |
| Uses | (R)-MOP is used as a catalyst in the preparation of chiral tetrahydrobenzofuranone alkylideneboronates and oxindoles. Also used as a catalyst in the total synthesis of Oseltamivir Phosphate (O701000); an orally active inhibitor of influenza virus neuraminidase and an antiviral drug. | | Uses | Takasago Ligands and Complexes for Asymmetric ReactionsLigand used in palladium-catalyzed asymmetric hydrosilylation of olefins, palladium-catalyzed reduction of allylic esters, rhodium-catalyzed asymmetric addition reactions, and asymmetric amination reactions catalyzed by copper(I) complexes. | | Reactions | 1. Efficient catalyst for the enantoselective hydrosilyation of 1-alkenes to optically active 2-alcohols.
2. Ligand for palladium-catalyzed asymmetric reduction of allyltc esters.
3. Ligand for the rhodium-catalyzed asymmetric aryiation of imines with organostannanes.
4. Ligand for the rhodiunvcatalyzed asymmetrk: addition of aryl- and alkenyiborontc acids to Isatins.
5. Ligand for desymmetrizatlon of malonamides via an enantiosetective intramolecular Buchwatd-Hartwig reaction.
| | General Description | R-MOP is a phosphine ligand with a bis-naphthalene backbone. |
| (R)-MOP Preparation Products And Raw materials |
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