(S)-(-)-2-Methyl-2-propanesulfinamide

CAS No.：343338-28-3

Other grades of this product :

(S)-(-)-2-Methyl-2-propanesulfinamide Basic information

Description

Product Name:	(S)-(-)-2-Methyl-2-propanesulfinamide
Synonyms:	2-METHYL-2-PROPANE-SULFINAMIDE(S-ISOMER);(S)-tert-Butylsulfinamide, (>98.0% ee), 97+%;(S)-(-)-2-METHYL-2-PROPANESULPHINAMIDE;(S)-2-METHYLPROPANE-2-SULFINAMIDE;(S)-(-)-2-METHYL-PROPANE-2-SULFINIC ACID AMIDE;(S)-(-)-TERT-BUTYLSULFINAMIDE;(S)-(-)-TERT-BUTYL SULPHINAMIDE;(S)-(-)-T-BUTYLMETHYLSULFINAMIDE
CAS:	343338-28-3
MF:	C4H11NOS
MW:	121.2
EINECS:	640-158-3
Product Categories:	Asymmetric Synthesis;Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry;CHIRAL CHEMICALS;Sulfur Compounds;Asymmetric Synthesis;blocks;BuildingBlocks;Sulfonamides;chiral;CHIRAL COMPOUNDS;Chiral Auxiliaries;Sulfur-Based;Synthetic Flavours & Fragrances;organosulfur compound;bc0001
Mol File:	343338-28-3.mol

(S)-(-)-2-Methyl-2-propanesulfinamide Chemical Properties

Melting point	97-101 °C(lit.)
alpha	-4.5 º (c=1, CHCl3)
Boiling point	220.0±23.0 °C(Predicted)
density	1.124
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	10.11±0.50(Predicted)
form	Crystalline Powder
color	White
optical activity	[α]20/D 4.5°, c = 1 in chloroform
Stability:	store cold
InChIKey	CESUXLKAADQNTB-SSDOTTSWSA-N
CAS DataBase Reference	343338-28-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn,F
Risk Statements	11-19-36/37-40
Safety Statements	16-26-36/37-24/25
WGK Germany	3
Hazard Note	Irritant/Keep Cold
TSCA	No
HS Code	29309090

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

(S)-(-)-2-Methyl-2-propanesulfinamide Usage And Synthesis

Description	Acid labile protecting groups are important in organic synthesis. The tert‐butyl group is commonly used for protection of a large variety of functional groups, e.g., acids, alcohols, phenols, and sulfonamides. Among them, s-tert-butyl sulfonamide is a chiral ligand used in pharmaceutical compositions. P, n-sulfoxide imine ligands were synthesized by condensation of s-tert-butylsulfonamide with aldehydes and ketones, and they can be used for asymmetric hydrogenation of olefins under iridium catalysis.
Physical properties	white to light yellow crystal powde
Uses	It is also employed as a reagent for synthesizing chiral amines.
Uses	(S)-(-)-2-Methyl-2-propanesulfinamide is used in Suzuki reaction. It is also employed as a reagent for synthesizing chiral amines. It acts as a chiral auxiliary used in an asymmetric synthesis of trifluoroethylamines by conversion of trifluoroacetaldehyde to a chiral imine. It is also involved in the transformation of P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. Further, it serves as a reagent for the preparation of chemicals and pharmaceutical intermediates.

(S)-(-)-2-Methyl-2-propanesulfinamide Preparation Products And Raw materials

Preparation Products

(S,E)-N-(2-(tert-butyldimethylsilyloxy)ethylidene)-2-methylpropane-2-sulfinamide

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