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| Cabotegravir (GSK744, GSK1265744) Basic information |
| Product Name: | Cabotegravir (GSK744, GSK1265744) | | Synonyms: | GSK1265744;GSK744;(3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide;Cabotegravir (GSK744, GSK1265744);Cabotegravir Free Acid;Cabotegravir;Cyclic pyranopterin;SK744, GSK1265744 | | CAS: | 1051375-10-0 | | MF: | C19H17F2N3O5 | | MW: | 405.35 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 1051375-10-0.mol |
| Cabotegravir (GSK744, GSK1265744) Chemical Properties |
| Boiling point | 664.0±55.0 °C(Predicted) | | density | 1.57±0.1 g/cm3(Predicted) | | solubility | insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming | | form | solid | | pka | 4.50±1.00(Predicted) |
| Cabotegravir (GSK744, GSK1265744) Usage And Synthesis |
| Biological Activity | Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2. | | Mechanism of action | Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself. |
| Cabotegravir (GSK744, GSK1265744) Preparation Products And Raw materials |
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