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| Trifluoroacetamide Basic information |
| Trifluoroacetamide Chemical Properties |
| Melting point | 65-70 °C (lit.) | | Boiling point | 162.5 °C (lit.) | | density | 1.4176 (estimate) | | Fp | 162-164°C | | storage temp. | Store below +30°C. | | solubility | 460 g/L (20°C) | | pka | 12.33±0.50(Predicted) | | form | Crystalline Powder or Crystals | | color | White to pale yellow or beige | | PH | 3.6 (460g/l, H2O, 23℃) | | Water Solubility | 460 g/L (20 ºC) | | BRN | 1753625 | | InChIKey | NRKYWOKHZRQRJR-UHFFFAOYSA-N | | LogP | 0.725 at 23℃ and pH4.83 | | Dissociation constant | 0 at 23℃ | | CAS DataBase Reference | 354-38-1(CAS DataBase Reference) | | NIST Chemistry Reference | Acetamide, 2,2,2-trifluoro-(354-38-1) | | EPA Substance Registry System | Acetamide, 2,2,2-trifluoro- (354-38-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | 1759 | | WGK Germany | 3 | | Hazard Note | Harmful/Irritant | | TSCA | T | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29241900 |
| Trifluoroacetamide Usage And Synthesis |
| Chemical Properties | white to pale yellow or beige crystalline powder | | Uses | 2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups. | | Application | Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies. | | Preparation | One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses. 10.1142/S1088424621500292 | | General Description | Trifluoroacetamide is a good quencher of tryptophan fluorescence. |
| Trifluoroacetamide Preparation Products And Raw materials |
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