2,6-Dimethoxybenzoic acid

CAS No.：1466-76-8

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2,6-Dimethoxybenzoic acid Basic information

Product Name:	2,6-Dimethoxybenzoic acid
Synonyms:	AKOS BBS-00003742;2,6-DIMETHOXYBENZOIC ACID;tert-Butylhydrazine2,6-Dimethoxybenzoic acid;RARECHEM AL BO 1076;2,6-dimethoxy-benzoicaci;Benzoicacid,2,6-dimethoxy-;2,6-Dimethoxybenzoic;γ-Resorcylic acid diMethyl ether
CAS:	1466-76-8
MF:	C9H10O4
MW:	182.17
EINECS:	215-985-4
Product Categories:	Agrochemical intermediate;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;C9;Carbonyl Compounds;Carboxylic Acids
Mol File:	1466-76-8.mol

2,6-Dimethoxybenzoic acid Chemical Properties

Melting point	185-187 °C (lit.)
Boiling point	275.56°C (rough estimate)
density	1.2481 (rough estimate)
refractive index	1.4500 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	14.7g/l soluble
form	Crystalline Powder
pka	pK1:3.44 (25°C)
color	White to off-white
Water Solubility	0.35 g/100 mL (25 ºC)
BRN	2212190
InChIKey	MBIZFBDREVRUHY-UHFFFAOYSA-N
CAS DataBase Reference	1466-76-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 2,6-dimethoxy-(1466-76-8)
EPA Substance Registry System	Benzoic acid, 2,6-dimethoxy- (1466-76-8)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-22
Safety Statements	26-36-37/39
WGK Germany	3
RTECS	DG8598725
TSCA	Yes
HS Code	29189010

MSDS Information

Provider	Language
2,6-Dimethoxybenzoic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

2,6-Dimethoxybenzoic acid Usage And Synthesis

Chemical Properties	white to off-white crystalline powder
Uses	2,6-Dimethoxybenzoic Acid is used in the synthesis of indoles as well as coumarins related to Novobiocin (N888500), used as potent inhibitors of heat-shock protein 90 in the treatment of breast cancer.
Synthesis Reference(s)	Synthetic Communications, 22, p. 13, 1992 DOI: 10.1080/00397919208021074
Flammability and Explosibility	Notclassified
Purification Methods	Crystallise the acid from water or 1,1-dichloroethane (m 187.5-188.5o). [Beilstein 10 H 388, 10 I 185, 10 II 259, 10 III 1401, 10 IV 1456.]

2,6-Dimethoxybenzoic acid Preparation Products And Raw materials

Raw materials	Potassium carbonate-->Resorcinol-->2,6-Dihydroxybenzoic acid
Preparation Products	1-(2,6-DIMETHOXYBENZYL)PIPERIDIN-4-AMINE HYDROCHLORIDE-->2,6-Dimethoxybenzylbromide-->2,6-DIMETHOXYBENZYL ALCOHOL-->Remoxipride-->2,6-Dimethoxybenzaldehyde-->Methyl 2,6-dimethoxybenzoate-->2',6'-Dimethoxyacetophenone-->methicillin

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