2,6-Dimethoxybenzoic acid

2,6-Dimethoxybenzoic acid
  • CAS No.:1466-76-8
Other grades of this product :
2,6-Dimethoxybenzoic acid Basic information
Product Name:2,6-Dimethoxybenzoic acid
Synonyms:AKOS BBS-00003742;2,6-DIMETHOXYBENZOIC ACID;tert-Butylhydrazine2,6-Dimethoxybenzoic acid;RARECHEM AL BO 1076;2,6-dimethoxy-benzoicaci;Benzoicacid,2,6-dimethoxy-;2,6-Dimethoxybenzoic;γ-Resorcylic acid diMethyl ether
CAS:1466-76-8
MF:C9H10O4
MW:182.17
EINECS:215-985-4
Product Categories:Agrochemical intermediate;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;C9;Carbonyl Compounds;Carboxylic Acids
Mol File:1466-76-8.mol
2,6-Dimethoxybenzoic acid Chemical Properties
Melting point 185-187 °C (lit.)
Boiling point 275.56°C (rough estimate)
density 1.2481 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility 14.7g/l soluble
form Crystalline Powder
pkapK1:3.44 (25°C)
color White to off-white
Water Solubility 0.35 g/100 mL (25 ºC)
BRN 2212190
InChIKeyMBIZFBDREVRUHY-UHFFFAOYSA-N
CAS DataBase Reference1466-76-8(CAS DataBase Reference)
NIST Chemistry ReferenceBenzoic acid, 2,6-dimethoxy-(1466-76-8)
EPA Substance Registry SystemBenzoic acid, 2,6-dimethoxy- (1466-76-8)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-36-37/39
WGK Germany 3
RTECS DG8598725
TSCA Yes
HS Code 29189010
MSDS Information
ProviderLanguage
2,6-Dimethoxybenzoic acid English
SigmaAldrich English
ACROS English
ALFA English
2,6-Dimethoxybenzoic acid Usage And Synthesis
Chemical Propertieswhite to off-white crystalline powder
Uses2,6-Dimethoxybenzoic Acid is used in the synthesis of indoles as well as coumarins related to Novobiocin (N888500), used as potent inhibitors of heat-shock protein 90 in the treatment of breast cancer.
Synthesis Reference(s)Synthetic Communications, 22, p. 13, 1992 DOI: 10.1080/00397919208021074
Flammability and ExplosibilityNotclassified
Purification MethodsCrystallise the acid from water or 1,1-dichloroethane (m 187.5-188.5o). [Beilstein 10 H 388, 10 I 185, 10 II 259, 10 III 1401, 10 IV 1456.]

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