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| 1-BROMO-2-BUTYNE Basic information |
| 1-BROMO-2-BUTYNE Chemical Properties |
| Boiling point | 40-41 °C/20 mmHg (lit.) | | density | 1.519 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.508(lit.) | | Fp | 97 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Miscible with acetonitrile. | | form | Liquid | | Specific Gravity | 1.519 | | color | Clear pale yellow-greenish | | BRN | 605306 | | InChIKey | LNNXOEHOXSYWLD-UHFFFAOYSA-N | | CAS DataBase Reference | 3355-28-0(CAS DataBase Reference) |
| Risk Statements | 10 | | Safety Statements | 16-24/25 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | F | 10-23 | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29033990 |
| 1-BROMO-2-BUTYNE Usage And Synthesis |
| Chemical Properties | Clear pale yellow-greenish liquid | | Uses | 1-Bromo-2-butyne is used in the preparation of six to eight annulated ring compounds in reaction with indoles and pseudopterane (+/-)-Kallolide B, which is a marine natural product. Further, it acts as a precursor in the preparation of axially chiral teranyl compounds, alkylation of L-tryptophan methyl ester, 4-butynyloxybenzene sulfonyl chloride and mono-propargylated diene derivative. In addition to this, it is also used in the synthesis of isopropylbut-2-ynylamine, allenylcyclobutanol derivatives, allyl-[4-(but-2-ynyloxy)phenyl]sulfane, allenylindium and axially chiral teranyl compounds. | | Preparation | 1-bromo-2-butyne is obtained by reacting 2-butyn-1-ol and organic solvent, pyridine.First react bromoethane with metal magnesium in THF to prepare Grignard reagent, then add paraformaldehyde to Grignard reagent for Grignard reaction, separate and recover after Grignard reaction 2-butyn-1-ol, then mix 2-butyn-1-ol with organic solvent and pyridine, add phosphorus tribromide dropwise for bromination reaction, separate and recover the product after bromination reaction. | | General Description | 1-Bromo-2-butyne is a propargyl bromide derivative. It is one of the constitutional isomer of bromo butyne. Its Br-loss threshold photoionization breakdown diagram has been analyzed to derive dissociative photoionization thresholds to C4H5+ production. It participates in the preparation of linagliptin. |
| 1-BROMO-2-BUTYNE Preparation Products And Raw materials |
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