| 2-Hydroxyisobutyric acid Basic information |
| Product Name: | 2-Hydroxyisobutyric acid |
| Synonyms: | Propanoic acid, 2-methyl-2-hydroxy-;A-HYDROXY-ISO-BUTYRIC ACID;2-MethyllaCLic Acid;alpha-Hydroxyisobutyric acid 98%;2-Hydroxyisobutyric acid for synthesis;RARECHEM AL BO 0199;alpha-Hydroxyisobutanoic acid;Hydroxydimethylacetic acid |
| CAS: | 594-61-6 |
| MF: | C4H8O3 |
| MW: | 104.1 |
| EINECS: | 209-848-8 |
| Product Categories: | Carboxylic Acids;Chemical Synthesis;FINE Chemical & INTERMEDIATES;Organic acids;Building Blocks;Organic Building Blocks;C1 to C5;Carbonyl Compounds;bc0001 |
| Mol File: | 594-61-6.mol |
| 2-Hydroxyisobutyric acid Chemical Properties |
| Melting point | 76-80 °C(lit.) |
| Boiling point | 84 °C1.5 mm Hg(lit.) |
| density | 11412 |
| refractive index | 1.4761 (estimate) |
| Fp | 114°C/12mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | water: soluble10%, clear to very slightly hazy, colorless |
| pka | pK1:3.717 (25°C,μ=0.1) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water, ether, alcohol, methanol and hot benzene. |
| BRN | 1744739 |
| CAS DataBase Reference | 594-61-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanoic acid, 2-hydroxy-2-methyl-(594-61-6) |
| EPA Substance Registry System | Propanoic acid, 2-hydroxy-2-methyl- (594-61-6) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41-36/37/38 |
| Safety Statements | 26-39-25-36 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29181980 |
| MSDS Information |
| Provider | Language |
|---|---|
| 2-Methyllactic acid | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 2-Hydroxyisobutyric acid Usage And Synthesis |
| Chemical Properties | white to off-white needle-like crystals or |
| Uses | 2-Hydroxyisobutyric acid is used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry. |
| Uses | 2-Hydroxyisobutyric acid is used as an electrolyte in the separation of the metal ions by on-line cyclic voltammetry. It is also used as a building block for the synthesis of polymers. Its conjugate base, 2-hydroxybutyrate is utilized to catabolize L-threonine as well as synthesize glutathione. Further, it is used as an indicator for the early detection insulin resistance in non-diabetic subjects. |
| Uses | α-Hydroxyisobutyric acid was used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry. |
| Definition | ChEBI: A 2-hydroxy monocarboxylic acid that is isobutyric acid bearing a hydroxy substituent at position 2. It is a metabolite of methyl tertiary-butyl ether. |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 23, p. 1488, 1958 DOI: 10.1021/jo01104a022 |
| General Description | α-Hydroxyisobutyric acid (2-hydroxyisobutyric acid) is the building block for polymer synthesis. It forms complexes with Eu(III) and has been studied by time resolved fluorescence spectroscopy. |
| 2-Hydroxyisobutyric acid Preparation Products And Raw materials |
| Raw materials | 1,2-BENZENEDISULFONYL DICHLORIDE |
| Preparation Products | 2-Methyl-2-propenoic acid cyclohexyl ester-->Ethyl 2-hydroxyisobutyrate-->2-Methyl-2-hydroxypropionamide-->1-Chlorocarbonyl-1-methylethyl acetate |
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