D-DOPA

D-DOPA
  • CAS No.:5796-17-8

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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D-DOPA Basic information
Product Name:D-DOPA
Synonyms:D-3-(3,4-Dihydroxyphenyl)alanine;D-Tyrosine,3-hydroxy-;H-D-TYR(3-HYDROXY)-OH;H-D-PHE(3,4-DI-HYDROXY)-OH;D-3-HYDROXYTYROSINE;D-BETA-(3,4-DIHYDROXYPHENYL)ALANINE;D-3,4-DIHYDROXYPHENYLALANINE;D-DOPA
CAS:5796-17-8
MF:C9H11NO4
MW:197.19
EINECS:227-343-0
Product Categories:Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents;Neurochemicals
Mol File:5796-17-8.mol
D-DOPA Chemical Properties
Melting point 276-278 °C(lit.)
alpha D11 +13.0° (c = 5.27 in 1N HCl)
Boiling point 448.4±45.0 °C(Predicted)
density 1.468±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility 0.5 M HCl: soluble
form powder
pka2.24±0.20(Predicted)
color white to tan
Merck 13,3454
BRN 2417637
CAS DataBase Reference5796-17-8(CAS DataBase Reference)
Safety Information
WGK Germany 3
F 10-23
HS Code 2922500090
MSDS Information
ProviderLanguage
SigmaAldrich English
D-DOPA Usage And Synthesis
Chemical PropertiesTan Solid
UsesA DOPA enantiomer that lacks biological activity.
UsesD-DOPA (Levodopa EP Impurity D) is a DOPA enantiomer that lacks biological activity.
DefinitionChEBI: The D-enantiomer of dopa.
Biochem/physiol ActionsDOPA enantiomer that lacks biological activity.
Purification MethodsLikely impurities are vanillin, hippuric acid, 3-methoxytyrosine and 3-aminotyrosine. DOPA recrystallises from large volumes of H2O forming colourless white needles; its solubility in H2O is 0.165%, but it is insoluble in EtOH, *C6H6, CHCl3, and EtOAc. Also crystallise it by dissolving it in dilute HCl and adding dilute ammonia to give pH 5, under N2. Alternatively, crystallise it from dilute aqueous EtOH. It is rapidly oxidised in air when moist, and darkens, particularly in alkaline solution. Dry it in vacuo at 70o in the dark, and store it in a dark container preferably under N2. It has at 220.5nm (log 3.79) and 280nm (log 3.42) in 0.001N max HCl. [Yamada et al. Chem Pharm Bull Jpn 10 693 1962, Bretschneider et al. Helv Chim Acta 56 2857 1973, NMR: Jardetzky & Jardetzky J Biol Chem 233 383 1958, Beilstein 4 IV 2492, 2493.]
D-DOPA Preparation Products And Raw materials

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