5-Amino-2-chloropyridine

CAS No.：5350-93-6

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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5-Amino-2-chloropyridine Basic information

Product Name:	5-Amino-2-chloropyridine
Synonyms:	3-PYRIDINAMINE, 6-CHLORO-;3-AMINO-6-CHLOROPYRIDINE;6-CHLOROPYRIDIN-3-AMINE;6-CHLORO-PYRIDIN-3-YLAMINE;5-AMINO-2-CHLOROPYRIDINE;2-CHLORO-5-AMINOPYRIDINE;TIMTEC-BB SBB004234;AMINO CHLOROPYRIDINE
CAS:	5350-93-6
MF:	C5H5ClN2
MW:	128.56
EINECS:	226-322-3
Product Categories:	Chloropyridines;Halopyridines;Boronic Acid;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PYRIDINE;Amines;blocks;Pyridines;pyridine derivative;Pyridine Series;Pyridines derivates;Amino-pyridine series;compounds of pyridine;bc0001
Mol File:	5350-93-6.mol

5-Amino-2-chloropyridine Chemical Properties

Melting point	81-83 °C(lit.)
Boiling point	205.39°C (rough estimate)
density	1.2417 (rough estimate)
refractive index	1.5110 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	1.94±0.10(Predicted)
form	powder to crystal
color	White to Brown
BRN	108891
InChIKey	QAJYCQZQLVENRZ-UHFFFAOYSA-N
CAS DataBase Reference	5350-93-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333999

MSDS Information

Provider	Language
5-Amino-2-chloropyridine	English
SigmaAldrich	English
ACROS	English
ALFA	English

5-Amino-2-chloropyridine Usage And Synthesis

Chemical Properties	Light yellow to brown crystalline powder
Uses	5-Amino-2-chloropyridine was used in the synthesis of [²H₅]2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine. It was used in identification and evaluation of molecularly imprinted polymers for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals.
General Description	5-Amino-2-chloropyridine undergoes Suzuki-Miyaura coupling with sterically hindered 2,6-dimethylphenylboronic acid. It undergoes facile temperature dependent displacement of chloride by bromide via Sandmeyer reaction to yield 2,5-dibromopyridine.

5-Amino-2-chloropyridine Preparation Products And Raw materials

Raw materials

6-Chloronicotinamide-->2-Chloro-5-iodopyridine-->2-Chloro-5-nitropyridine-1-oxide-->Boron trifluoride methyl sulfide complex-->2-Amino-5-fluoropyridine-->2-Chloro-5-nitropyridine

Preparation Products

5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID-->5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID-->5-AMINOPYRIDINE-2-BORONIC ACID PINACOL ESTER-->5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE-->2-Chloro-5-fluoropyridine-->3-Aminopyridine-->3-Amino-6-hydroxypyridine-->3-Pyridinamine,6-chloro-N-methyl-(9CI)-->ethyl 4,6-dichloro-1,5-naphthyridine-3-carboxylate-->3-amino-6-chloro-1H-pyridine-2-thione

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