2-Hydroxynicotinic acid

CAS No.：609-71-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Hydroxynicotinic acid Basic information

Product Name:	2-Hydroxynicotinic acid
Synonyms:	1,2-dihydro-2-oxonicotinic acid;3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-;2-Hydroxynicotinic acid 98%;2-Hydroxynicotinicacid,99%;2-Hydroxy-3-picolinic acid;2-HYDROXYNICOTINIC ACID;2-HYDROXYPYRIDINE-3-CARBOXYLIC ACID;2-HYDROXY-3-PYRIDINECARBOXYLIC ACID
CAS:	609-71-2
MF:	C6H5NO3
MW:	139.11
EINECS:	210-198-2
Product Categories:	Pyridines, Pyrimidines, Purines and Pteredines;Organic acids;blocks;Carboxes;Pyridines;Pyridine;CHIRAL CHEMICALS;Aromatics;Heterocycles;Nicotine Derivatives;Halogenated Heterocycles;bc0001
Mol File:	609-71-2.mol

2-Hydroxynicotinic acid Chemical Properties

Melting point	258-261 °C(lit.)
Boiling point	255.04°C (rough estimate)
density	1.4429 (rough estimate)
refractive index	1.5423 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	0.1 M NaOH: 0.1 g/mL, clear
pka	2.40±0.20(Predicted)
form	Powder
color	White to light yellow
BRN	119028
InChIKey	UEYQJQVBUVAELZ-UHFFFAOYSA-N
CAS DataBase Reference	609-71-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

2-Hydroxynicotinic acid Usage And Synthesis

Chemical Properties	White to light yellow powder
Uses	2-Hydroxynicotinic acid is used in chemical synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Definition	ChEBI: 2-Hydroxynicotinic acid is a member of pyridines and an aromatic carboxylic acid. It is a derivative of nicotinic acid, was found to exist in four polymorphs. It is used as a growth factor in Erwinia amylovora growth (pear and apple blossoms).

2-Hydroxynicotinic acid Preparation Products And Raw materials

Raw materials	2-Aminonicotinic acid-->2-Chloronicotinic acid-->2-Hydroxy-3-cyanopyridine-->6-Quinolinecarboxylic acid-->2-Fluoronicotinic acid-->2-Bromonicotinic acid-->3-Bromo-2-hydroxypyridine-->CARBON DIOXIDE-->Nicotinic acid N-oxide
Preparation Products	5-AMINO-2-CHLORO-NICOTINIC ACID-->2-Chloro-5-nitronicotinic acid-->2,5-Dichloronicotinic acid-->5-Bromo-2-chloronicotinic acid-->METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE-->2-Hydroxy-5-nitronicotinic acid-->2-Hydroxy-5-pyridinecarboxylic acid

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