Other grades of this product :
| clofedanol Basic information |
| Product Name: | clofedanol | | Synonyms: | 1-(2-chlorophenyl)-3-dimethylamino-1-phenylpropan-1-ol;clofedanol;clofedano;CHLOPHENDIANOL;1-o-Chlorophenyl-1-phenyl-3-dimethylamino-1-propanol;1-o-Chlorophenyl-3-dimethylamino-1-phenylpropan-1-ol;1-Phenyl-1-(o-chlorophenyl)-3-dimethylaminopropanol;1-Phenyl-1-o-chlorophenyl-3-(dimethylamino)-1-propanol | | CAS: | 791-35-5 | | MF: | C17H20ClNO | | MW: | 289.7998 | | EINECS: | 2123409 | | Product Categories: | | Mol File: | 791-35-5.mol |
| clofedanol Chemical Properties |
| Melting point | 120° | | CAS DataBase Reference | 791-35-5 |
| Toxicity | LD50 i.v. in mice: 70 mg/kg (Lorenz) |
| clofedanol Usage And Synthesis |
| Originator | Detigon,Bayer,W. Germany,1958 | | Uses | (±)-Chlophedianol is an inhalation eutectic compound, used for treatment of respiratory diseases.Also, used in preparation of Deuterated morphine derivatives useful in treatment of pain or as as antitussive agents with reduced risk of possibility of drug abuse. | | Manufacturing Process | This compound may be produced by reacting o-chlorobenzophenone with
acetonitrile in the presence of sodium amide or another strongly basic
condensing agent, to form the nitrile of beta-phenyl-beta-o-chlorophenyl-hydracrylic acid, which is then hydrogenated to yield 1-phenyl-1-o-chlorophenyl-3-aminopropanol-1. The latter intermediate compound is
subsequently dimethylated with an agent such as methyl sulfate to provide
the desired end product 1-o-chlorophenyl-1-phenyl-3-dimethylaminopropanol. | | Therapeutic Function | Antitussive |
| clofedanol Preparation Products And Raw materials |
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