2-Hydroxybenzimidazole

CAS No.：615-16-7

Other grades of this product :

2-Hydroxybenzimidazole Basic information

Product Name:	2-Hydroxybenzimidazole
Synonyms:	o-phenylene urea;RARECHEM AQ NN 0099;TIMTEC-BB SBB004209;TIMTEC-BB SBB000067;2-Hydroxybenzimidazole,2(1H)-Benzimidazolone (1H-Benzimidazol-2-ol);2-hydroxy and iMidazole;2H-Benzimidazol-2-one, 1,3-dihydro-;o-Benzimidazolone
CAS:	615-16-7
MF:	C7H6N2O
MW:	134.14
EINECS:	210-412-4
Product Categories:	Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Imidazol&Benzimidazole;BENZIMIDAZOLE;PHARMACEUTICAL INTERMEDIATES;Benzimidazole Series;pharmaceutical;Benzimidazoles;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;H;Heterocyclic Building Blocks;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;API intermediates;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:	615-16-7.mol

2-Hydroxybenzimidazole Chemical Properties

Melting point	>300 °C (lit.)
Boiling point	247.23°C (rough estimate)
density	1.2296 (rough estimate)
refractive index	1.5880 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	0.543g/l
form	Crystalline Powder
pka	11.95±0.10(Predicted)
color	Off-white to pale brown
Water Solubility	insoluble
BRN	119866
LogP	1.17 at 23℃ and pH6.2-6.4
CAS DataBase Reference	615-16-7(CAS DataBase Reference)
NIST Chemistry Reference	2H-Benzimidazol-2-one, 1,3-dihydro-(615-16-7)
EPA Substance Registry System	2H-Benzimidazol-2-one, 1,3-dihydro- (615-16-7)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-24/25-37/39
WGK Germany	1
RTECS	DE1625000
Hazard Note	Irritant
TSCA	Yes
HS Code	29339990
Toxicity	LD50 scu-mus: 620 mg/kg ARZNAD 8,42,58

MSDS Information

Provider	Language
2-Hydroxybenzimidazole	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Hydroxybenzimidazole Usage And Synthesis

Chemical Properties	off-white to pale brown crystalline powder
Uses	A metabolite of the neuroleptic Droperidol (D679500).
Uses	2-Hydroxybenzimidazole (Lansoprazole EP Impurity D(Rabeprazole EP Impurity K)) is a metabolite of the neuroleptic Droperidol (D679500).
Synthesis Reference(s)	The Journal of Organic Chemistry, 33, p. 2543, 1968 DOI: 10.1021/jo01270a093Synthesis, p. 322, 1991 DOI: 10.1055/s-1991-26457Tetrahedron Letters, 22, p. 2431, 1981 DOI: 10.1016/S0040-4039(01)92925-9
Safety Profile	Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic vapors of NOx.

2-Hydroxybenzimidazole Preparation Products And Raw materials

Raw materials	S,S-bis(1-phenyl-1H-tetrazol-5-yl) dithiocarbonate-->1-Phenyltetrazole-5-thiol-->o-Phenylenediamine-->phenyl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylate-->1,2-Benzenediamine, N,N'-bis(trimethylsilyl)--->Benzenecarboximidic acid, 2-amino- (9CI)-->(2-aminophenyl)(1H-benzo[d][1,2,3]triazol-1-yl)methanone-->2-AMINO-N-HYDROXYBENZENECARBOXAMIDE-->p-Tolyl isocyanate
Preparation Products	5-IODO-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE-->Basic Yellow 24-->BASIC YELLOW 40

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