2-Methoxy-5-nitrophenol
2-Methoxy-5-nitrophenol
  • CAS No.:636-93-1
Other grades of this product :
2-Methoxy-5-nitrophenol Basic information
Product Name:2-Methoxy-5-nitrophenol
Synonyms:5 nitroguaiacol, 2-methoxy-5-nitrophenol;Phenol, 2-methoxy-5-nitro-;2-Methoxy-5-nitrophenol 98%;2-METHOXY-5-NITROPHENOL / 5-NITROGUAIACOL;2-METHOXY-5-NITROANILINE;2-Methoxy-5-nitrophenol ,99%;2-Methoxy-5-nitrophe;2-Hydroxy-1-methoxy-4-nitrobenzene
CAS:636-93-1
MF:C7H7NO4
MW:169.13
EINECS:211-269-0
Product Categories:Aromatic Phenols;Phenoles and thiophenoles;Building Blocks;C6 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Phenols
Mol File:636-93-1.mol
2-Methoxy-5-nitrophenol Chemical Properties
Melting point 103-107 °C (lit.)
Boiling point 110-112 °C/1 mmHg (lit.)
density 1.3375 (estimate)
refractive index 1.5830 (rough estimate)
Fp 110-112°C/1mm
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka8.31±0.19(Predicted)
color Light Yellow to Light Brown
BRN 2047074
InChIKeyKXKCTSZYNCDFFG-UHFFFAOYSA-N
CAS DataBase Reference636-93-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26-36
RIDADR 2811
WGK Germany 3
Hazard Note Irritant
PackingGroup III
HS Code 29095090
MSDS Information
ProviderLanguage
2-Methoxy-5-nitrophenol English
SigmaAldrich English
ALFA English
2-Methoxy-5-nitrophenol Usage And Synthesis
Chemical PropertiesYellow to light brown powder
Uses2-Methoxy-5-nitrophenol is used in the synthesis of potent VEGF and tyrosine kinase inhibitors. Also used in the synthesis of GABA analogues and phosphodiesterase inhibitors such as rolipram.
Synthesis Reference(s)Chemical and Pharmaceutical Bulletin, 28, p. 1287, 1980 DOI: 10.1248/cpb.28.1287
General Description2-Methoxy-5-nitrophenol is the substitution photoproduct formed on irradiation of 2-chloro-4-nitroanisole at 25°C in aqueous NaOH.
2-Methoxy-5-nitrophenol Preparation Products And Raw materials
Preparation Products4,5-DIMETHOXY-2-NITROTOLUENE-->2-Fluoro-4-nitrophenol-->2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE-->4-NITROCATECHOL

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