3-Maleimidopropionic acid

CAS No.：7423-55-4

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3-Maleimidopropionic acid Basic information

Product Name:	3-Maleimidopropionic acid
Synonyms:	N-(2-CARBOXYETHYL)MALEIMIDE;N-BETA-MALEIMIDOPROPIONIC ACID;MPA-OH;N-MALEOYL-BETA-ALANINE;RARECHEM AL CD 0912;AKOS BC-0729;3-MALEIMIDOPROPIONIC ACID;3-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-PROPIONIC ACID
CAS:	7423-55-4
MF:	C7H7NO4
MW:	169.13
EINECS:	616-069-0
Product Categories:	Maleimide Derivatives;N-Substituted Maleimides;N-Substituted Maleimides, Succinimides & Phthalimides;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents;Heterobifunctional Crosslinker;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Cyclic Imides;Organic Building Blocks
Mol File:	7423-55-4.mol

3-Maleimidopropionic acid Chemical Properties

Melting point	103-106 °C (lit.)
Boiling point	382.5±25.0 °C(Predicted)
density	1.473±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	4.18±0.10(Predicted)
form	Solid
color	White
Water Solubility	Soluble in methanol, dimethyl formamide, alcohol and dimethyl sulfoxide. Slightly soluble in water.
Sensitive	Moisture Sensitive
BRN	1528952
InChIKey	IUTPJBLLJJNPAJ-UHFFFAOYSA-N
CAS DataBase Reference	7423-55-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
F	10-21
HS Code	29252900

MSDS Information

Provider	Language
SigmaAldrich	English

3-Maleimidopropionic acid Usage And Synthesis

Description	3-Maleimidopropionic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Chemical Properties	White to Pale Yellow Solid
Uses	3-Maleimidopropionic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent.
Uses	A sulfhydryl reactive heterobifunctional crosslinking reagent.
General Description	N-Maleoyl-β-alanine (3-maleimidopropanoic acid) is an aliphatic N-substituted maleimide. It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.

3-Maleimidopropionic acid Preparation Products And Raw materials

Raw materials	Acetic acid-->Toluene-->Maleic anhydride-->2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE-->β-Alanine-->2,3-Pentanedione-->CIS-5-AZA-4-OXO-OCT-2-EN-DIOIC ACID
Preparation Products	2,5-Dimethylfuran-->Maleimide-PEG4-NHS Ester

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