N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE

CAS No.：677-43-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE Basic information

Product Name:	N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
Synonyms:	N,N-DIMETHYLPHOSPHORAMIC DICHLORIDE;N,N-DIMETHYLPHOSPHORAMIDIC DICHLORIDE;N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE;PHOSPHORIC ACID DIMETHYLAMIDE DICHLORIDE;DIMETHYLAMINOPHOSPHORYL DICHLORIDE;DIMETHYLAMINE PHOSPHORYL DICHLORIDE;DIMETHYLAMIDOPHOSPHORIC DICHLORIDE;DMPADC
CAS:	677-43-0
MF:	C2H6Cl2NOP
MW:	161.95
EINECS:	211-641-2
Product Categories:
Mol File:	677-43-0.mol

N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE Chemical Properties

Boiling point	77-79 °C/11 mmHg (lit.)
density	1.362 g/mL at 20 °C (lit.)
refractive index	n20/D 1.464
Fp	89-90°C/20mm
storage temp.	2-8°C
solubility	Miscible with dimethoxyethane.
pka	-6.60±0.70(Predicted)
Sensitive	Moisture Sensitive
BRN	969956
CAS DataBase Reference	677-43-0
EPA Substance Registry System	N,N-Dimethyl phosphoramidic dichloride (677-43-0)

Safety Information

Hazard Codes	C
Risk Statements	34-37
Safety Statements	26-36/37/39
RIDADR	UN 3265 8/PG 3
WGK Germany	3
RTECS	TB4025000
F	1-3-10
HazardClass	8
PackingGroup	II

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE Usage And Synthesis

Chemical Properties

Light yellow liquid

Uses

N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.

N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE Preparation Products And Raw materials

Preparation Products

DIMEFOX

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