2-Thiophenecarboxylic acid

2-Thiophenecarboxylic acid
  • CAS No.:527-72-0

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  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Thiophenecarboxylic acid Basic information
Uses
Product Name:2-Thiophenecarboxylic acid
Synonyms:2-Thenoic Acid 2-Thiophenic Acid Thiophene-2-carboxylic acid;LABOTEST-BB LT02016392;AKOS B022791;AKOS BBS-00003739;ALPHA-THENOIC ACID;2-THENOIC ACID;2-THIOPHENIC ACID;2-THIOPHENECARBOXYLIC ACID
CAS:527-72-0
MF:C5H4O2S
MW:128.15
EINECS:208-423-4
Product Categories:Building Blocks;C4 to C6;Heterocyclic Compounds;Miscellaneous;Chemical Synthesis;Heterocyclic Building Blocks;Thiophenes;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Thiophene&Benzothiophene;Organic acids;Building Blocks;Heterocyclic Building Blocks
Mol File:527-72-0.mol
2-Thiophenecarboxylic acid Chemical Properties
Melting point 125-127 °C(lit.)
Boiling point 260 °C(lit.)
density 1.42
refractive index 1.5160 (estimate)
Fp 259-261°C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Acetone (Slightly), Chloroform (Slightly)
form solid
pka3.49(at 25℃)
color White to Off-White
Water Solubility 80 g/L (20 ºC)
Merck 14,9354
BRN 110150
InChIKeyQERYCTSHXKAMIS-UHFFFAOYSA-N
CAS DataBase Reference527-72-0(CAS DataBase Reference)
NIST Chemistry Reference2-Thiophenecarboxylic acid(527-72-0)
EPA Substance Registry System2-Thiophenecarboxylic acid (527-72-0)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS XM8330200
Hazard Note Irritant
TSCA Yes
HS Code 29349990
MSDS Information
ProviderLanguage
Thiophene-2-carboxylic acid English
SigmaAldrich English
ACROS English
ALFA English
2-Thiophenecarboxylic acid Usage And Synthesis
Uses2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.
Chemical Propertieswhite to light yellow crystal powder
Uses2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.
DefinitionChEBI: A thiophenecarboxylic acid in which the carboxy group is located at position 2.
Synthesis Reference(s)The Journal of Organic Chemistry, 30, p. 3520, 1965 DOI: 10.1021/jo01021a055
Purification MethodsCrystallise the acid from water and dry it in a vacuum. The amide has m 181o(from H2O) and pK2 5 10.54(50% aqueous dioxane). [Beilstein 18 H 289, 18 I 438, 18 II 269, 18 III/IV 4011, 18/6 V 158.]

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