2,2,6,6-Tetramethyl-4-piperidinol

CAS No.：2403-88-5

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2,2,6,6-Tetramethyl-4-piperidinol Basic information

Product Name:	2,2,6,6-Tetramethyl-4-piperidinol
Synonyms:	TAA-OL;TRIACETONEAMINO ALCOHOL;Tetramethyl piperidylol;2,2,6,6-TETRAMETHYL-4-PIPERIDINOL 99+%;Triacetoneamino Alcohol TAA-ol;Triacetonalkamine;6-Tetramethyl-4-piperidinol;4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINE TAA-OL
CAS:	2403-88-5
MF:	C9H19NO
MW:	157.25
EINECS:	219-291-2
Product Categories:	Chemical intermediate;Aromatics;API intermediates;Heterocycles;Intermediates;Nitric Oxide Reagents;Industrial/Fine Chemicals;Nitrogen cyclic compounds;Miscellaneous
Mol File:	2403-88-5.mol

2,2,6,6-Tetramethyl-4-piperidinol Chemical Properties

Melting point	129-131 °C(lit.)
Boiling point	212-215 °C(lit.)
density	1.085
refractive index	1.4248 (estimate)
Fp	212-215°C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	methanol: 0.1 g/mL, clear
form	Crystals, Crystalline Powder and/or Chunks
pka	14.99±0.60(Predicted)
color	White to off-white or slightly beige
PH	11.2 (4g/l, H2O, 20℃)
Water Solubility	130 g/L (23 ºC)
BRN	105039
InChIKey	VDVUCLWJZJHFAV-UHFFFAOYSA-N
CAS DataBase Reference	2403-88-5(CAS DataBase Reference)
NIST Chemistry Reference	4-Piperidinol, 2,2,6,6-tetramethyl-(2403-88-5)
EPA Substance Registry System	4-Piperidinol, 2,2,6,6-tetramethyl- (2403-88-5)

Safety Information

Hazard Codes	Xi,C
Risk Statements	36/37/38-43-34
Safety Statements	26-36-45-36/37/39
RIDADR	UN3259 8/PG 2
WGK Germany	1
RTECS	TN7871675
Hazard Note	Irritant
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29333999

MSDS Information

Provider	Language
2,2,6,6-Tetramethyl-4-piperidinol	English
SigmaAldrich	English
ACROS	English
ALFA	English

2,2,6,6-Tetramethyl-4-piperidinol Usage And Synthesis

Chemical Properties	white to slightly beige crystalline powder
Uses	An intermediate in the preparation of Piperidinyloxy free radical derivatives.
Uses	2,2,6,6-tetramethyl-4-piperidinol has been used to study the irradiation of Camptothecin (CPT) in aerated dimethylsulfoxide (DMSO) solution that leads to formation of singlet oxygen.
Synthesis Reference(s)	The Journal of Organic Chemistry, 37, p. 2050, 1972 DOI: 10.1021/jo00977a047
Purification Methods	The piperidine crystallises from water as a hydrate and crystallises from dry ether or *C6H6 as the anhydrous base. The hydrochloride has m 282-284o (from EtOH/H2O), and the formate has m 207o(dec, from EtOH/EtOAc). [Mailey & Day J Org Chem 22 1061 1957, Beilstein 21 I 195, 21 III/IV 146, 21/1 V 159.]

2,2,6,6-Tetramethyl-4-piperidinol Preparation Products And Raw materials

Raw materials	4,4'-bis(2,2,6,6-tetramethylpiperidin-4-ol)-->1,2,2,6,6-Pentamethyl-4-piperidinol-->Triacetonamine-->2,2,6,6-Tetramethyl-4-piperidone hydrochloride-->N-BUTYL TRIACETONEDIAMINE-->DIPHENYLDIAZOMETHANE-->2,6-DIMETHYL-2,5-HEPTADIEN-4-ONE-->Butylamine
Preparation Products	LMI070

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