Eprazinone

Eprazinone
  • CAS No.:10402-90-1
Other grades of this product :
Eprazinone Basic information
Product Name:Eprazinone
Synonyms:EPRAZINONE;1-(2-phenyl-2-ethoxy)ethyl-4-(2-benzoyl)propylpiperazine;β-[4-(β-Ethoxyphenethyl)-1-piperazinyl]-α-methylpropiophenone;3-(4-(2-Ethoxy-2-phenylethyl)piperazin-1-yl)-2-Methyl-1-phenylpropan-1-one;1-Propanone, 3-[4-(2-ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-;1-(2-phenyl-2-ethoxyethyl)-4-(2-benzyloxypropyl)piperazine;2-(4-(beta-ethoxyphenethyl)-1-piperazinyl)methyl-propiophenon;3-(4-(2-ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-1-propano ne
CAS:10402-90-1
MF:C24H32N2O2
MW:380.52
EINECS:233-873-3
Product Categories:
Mol File:10402-90-1.mol
Eprazinone Chemical Properties
Boiling point 508.13°C (rough estimate)
density 1.0909 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Sealed in dry,Room Temperature
pka6.83±0.10(Predicted)
CAS DataBase Reference10402-90-1(CAS DataBase Reference)
Safety Information
MSDS Information
Eprazinone Usage And Synthesis
OriginatorMucitux,Riom,France,1969
DefinitionChEBI: A member of the class of piperazines in which the two amino hydrogens of piperazine are replaced by 2-benzoylpropyl and 2-ethoxy-2-phenylethyl groups.
Manufacturing Process61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g (0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and 0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The product is allowed to crystallize, then filtered and washed with alcohol. It is dried and recrystallized from methanol containing 10% H2O.There is thus obtained 60 g of a white crystalline powder soluble in water. Yield: 66%. Melting point: 160°C.
Therapeutic FunctionAntitussive
Eprazinone Preparation Products And Raw materials
Raw materialsPropiophenone-->Hydrochloric acid-->1,3,5-trioxane

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