Other grades of this product :
| ZONIPORIDE Basic information |
| Product Name: | ZONIPORIDE | | Synonyms: | N-[5-Cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carbonyl]guanidine;CP 597396;ZONIPORIDE;N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate;Zoniporide hydrochloride hydrate;1H-Pyrazole-4-carboxamide, N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-;N-carbamimidoyl-5-cyclopropyl-1-(5-quinolyl)pyrazole-4-carboxamide | | CAS: | 241800-98-6 | | MF: | C17H16N6O | | MW: | 320.35 | | EINECS: | | Product Categories: | | Mol File: | 241800-98-6.mol |
| ZONIPORIDE Chemical Properties |
| density | 1.54 | | storage temp. | 2-8°C | | solubility | H2O: soluble2mg/mL, clear (warmed) | | form | powder | | pka | 11.44±0.46(Predicted) | | color | white to tan |
| ZONIPORIDE Usage And Synthesis |
| Uses | Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication. | | Biochem/physiol Actions | Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM. |
| ZONIPORIDE Preparation Products And Raw materials |
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