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| 1-(6-nitropyridin-3-yl)piperazine Basic information |
| 1-(6-nitropyridin-3-yl)piperazine Chemical Properties |
| Boiling point | 422.8±40.0 °C(Predicted) | | density | 1.278±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | Chloroform; Methanol | | form | Solid | | pka | 8.50±0.10(Predicted) | | color | Yellow |
| 1-(6-nitropyridin-3-yl)piperazine Usage And Synthesis |
| Uses | 1-?(6-?Nitro-?3-?pyridinyl)?piperazine is a reagent used in the preparation of highly potent and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependant kinases as anticancer agents. Also is an impurity of Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. |
| 1-(6-nitropyridin-3-yl)piperazine Preparation Products And Raw materials |
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