2-Chloro-3-hydroxypyridine

CAS No.：6636-78-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Chloro-3-hydroxypyridine Basic information

Product Name:	2-Chloro-3-hydroxypyridine
Synonyms:	2-Chloro-3-hydroxypyridine≥ 99% (HPLC);2-CHLORO-PYRIDINE-3-OL;2-CHLOROPYRIDIN-3-OL;2-CHLORO-3-HYDROXYPYRIDINE;2-CHLORO-3-PYRIDINOL;2-CHLORO-3-HYDROXYPYRIDINE 2-CHLORO-PYRIDIN-3-OL;2-CHLORO-3-HYDROXYPYRIDINE (2-CHLORO-3-PYRIDINOL);2-chloro-3-pyridino
CAS:	6636-78-8
MF:	C5H4ClNO
MW:	129.54
EINECS:	229-635-3
Product Categories:	Chloropyridines;Halopyridines;PYRIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Pyridines derivatives;Imidazoles
Mol File:	6636-78-8.mol

2-Chloro-3-hydroxypyridine Chemical Properties

Melting point	170-172 °C (lit.)
Boiling point	316.2±22.0 °C(Predicted)
density	1.2309 (rough estimate)
refractive index	1.4510 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	4.32±0.10(Predicted)
form	Powder
color	Light beige
BRN	2216
InChIKey	RSOPTYAZDFSMTN-UHFFFAOYSA-N
CAS DataBase Reference	6636-78-8(CAS DataBase Reference)
NIST Chemistry Reference	2-Chloro-3-pyridinol(6636-78-8)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-37/39-24/25-36
WGK Germany	3
RTECS	UU7707000
HazardClass	IRRITANT
HS Code	29333990

MSDS Information

Provider	Language
2-Chloro-3-hydroxypyridine	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Chloro-3-hydroxypyridine Usage And Synthesis

Chemical Properties

light beige powder

Uses

2-Chloro-3-hydroxypyridine has been used in the preparation of 3-hydroxypyridine-2( 1 H)-selone. It has also been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles: benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine. the synthesis involves α and γ-activation of chloropyridines, as well as palladium-mediated reactions.

2-Chloro-3-hydroxypyridine Preparation Products And Raw materials

Preparation Products

2,3-Dimethoxypyridine-->2-Chloro-5-hydroxypyridine-->2,3-Dihydroxypyridine-->2-Chloro-3-methoxypyridine

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