ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

ALPHA-HYDROXY-GAMMA-BUTYROLACTONE
  • CAS No.:19444-84-9

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Basic information
Product Name:ALPHA-HYDROXY-GAMMA-BUTYROLACTONE
Synonyms:DIHYDRO-3-HYDROXY-2(3H)-FURANONE;2-HYDROXY-GAMMA-BUTYROLACTONE;3-HYDROXYTETRAHYDROFURAN-2-ONE;AKOS 224;ALPHA-HYDROXY-GAMMA-BUTYROLACTONE;4,5-Dihydro-3-hydroxy-2(3H)-furanone;α-Hydroxy-γ-butyrolactone;4,5-Dihydroxy-3-hydroxy-2(3H)-furanone
CAS:19444-84-9
MF:C4H6O3
MW:102.09
EINECS:
Product Categories:
Mol File:19444-84-9.mol
ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Chemical Properties
Boiling point 133 °C/10 mmHg (lit.)
density 1.309 g/mL at 25 °C (lit.)
refractive index n20/D 1.468(lit.)
Fp >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Sparingly), Methanol (Slightly)
pka13.07±0.20(Predicted)
form Viscous Liquid
color Clear colorless to yellow
BRN 80587
InChIKeyFWIBCWKHNZBDLS-UHFFFAOYSA-N
CAS DataBase Reference19444-84-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 23-24/25-36-26
WGK Germany 3
F 3-10
HS Code 29322090
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Usage And Synthesis
Chemical Propertiesclear colorless to yellow viscous liquid
Usesα-Hydroxy-γ-butyrolactone may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. 1 It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.
Usesα-Hydroxy-γ-butyrolactone may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.
General Descriptionα-Hydroxy-γ-butyrolactone is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde.
Purification MethodsIt has been purified by repeated fractionation and forms a colourless liquid. It has to be distilled at high vacuum; otherwise it will dehydrate. The acetox
ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Preparation Products And Raw materials
Preparation Products2,4-dihydroxy-Butanoic acid

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