1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent

CAS No.：887144-97-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Basic information

Description Reference

Product Name:	1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent
Synonyms:	1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent;3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole;1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole;Togni's Reagent;1,3-dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-benziodoxole;1,3-Dhydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-benziodoxole;3,3-DMethyl-1-(trifluoroMethyl)-1,2-benziodoxole;1,3-Dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-b
CAS:	887144-97-0
MF:	C10H10F3IO
MW:	330.09
EINECS:
Product Categories:
Mol File:	887144-97-0.mol

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Chemical Properties

Melting point	75-79 °C
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	powder
color	white to off-white
Stability:	Moisture Sensitive
InChIKey	HVAPLSNCVYXFDQ-UHFFFAOYSA-N

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37
RIDADR	1325
WGK Germany	3
TSCA	No
HazardClass	4.1
PackingGroup	Ⅲ
HS Code	29349990

MSDS Information

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Usage And Synthesis

Description	1,3-dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole is in the form of colorless, white solid. It is soluble in all common organic solvents. It is used as effective and very versatile reagent for trifluoromethylation reactions of a variety of compounds including secondary and primary aryland alkylphospines, phenols, peptides containing cysteine residues by SPPS and electrophilic S-trifluoromethylation, arenes and N-heterocycles, and electrophilic N-trifluoromethylation of arozoles.
Reference	J. Charpentier, N. Früh, A. Togni, Electrophilic Trifluoromethylation by use of hypervalent iodine reagents, Chemical Reviews, 2015, vol. 115, pp. 650-682
Chemical Properties	White to light yellow solid
Uses	Mild, electrophilic, hypervalent iodine CF3 reagent effective for the trifluoromethylation of a wide range of substrates.
Uses	Togni’s Reagent is used in trifluoromethylation reactions.

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Preparation Products And Raw materials

Raw materials	1,2-Benziodoxole, 1-(acetyloxy)-1,3-dihydro-3,3-dimethyl-->1-Fluoro-3,3-dimethyl-1,2-benziodoxole-->1-Chloro-1,3-dihydro-3,3-diMethyl-1,2-benziodoxole-->Methyl 2-iodobenzoate-->2-(2-iodophenyl)propan-2-ol
Preparation Products	1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene-->3-(trifluoroMethyl)pyrazin-2-aMine-->4-(TRIFLUOROMETHYL)DIPHENYL ETHER

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873