| 4'-Methoxyacetoacetanilide Basic information |
| Product Name: | 4'-Methoxyacetoacetanilide |
| Synonyms: | acetoacetyl-p-acetanisidine;ACETOACET-P-ANISIDIDE;ACETO ACET P-ANISIDINE;AAPA;AKOS B029142;Acetoacetanilide, 4'-methoxy-;alpha-APA;Butanamide, N-(4-methoxyphenyl)-3-oxo- |
| CAS: | 5437-98-9 |
| MF: | C11H13NO3 |
| MW: | 207.23 |
| EINECS: | 226-615-6 |
| Product Categories: | Aromatic amine products;Intermediates of Dyes and Pigments |
| Mol File: | 5437-98-9.mol |
| 4'-Methoxyacetoacetanilide Chemical Properties |
| Melting point | 115-118 °C |
| Boiling point | 346.25°C (rough estimate) |
| density | 1.1878 (rough estimate) |
| vapor pressure | 0.001Pa at 20℃ |
| refractive index | 1.5100 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Powder |
| pka | 11.35±0.46(Predicted) |
| color | White to Blue |
| Water Solubility | soluble |
| LogP | 0.85 at 23℃ and pH8.3-8.6 |
| CAS DataBase Reference | 5437-98-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Butanamide, 3-oxo-n-(4-methoxyphenyl)-(5437-98-9) |
| EPA Substance Registry System | Butanamide, N-(4-methoxyphenyl)-3-oxo- (5437-98-9) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 26-36/37/39 |
| RTECS | AK4598010 |
| HS Code | 2924297099 |
| MSDS Information |
| Provider | Language |
|---|---|
| 4'-Methoxyacetoacetanilide | English |
| ACROS | English |
| 4'-Methoxyacetoacetanilide Usage And Synthesis |
| Chemical Properties | WHITE TO VERY SLIGHTLY YELLOW POWDER |
| Uses | N-(4-Methoxyphenyl)-3-oxobutanamide is an intermediate in the synthesis of Tafenoquine-d3 Succinate is the labelled analog of Tatenoquine (T004760), a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase. |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 11, p. 803, 1946 DOI: 10.1021/jo01176a024 |
| 4'-Methoxyacetoacetanilide Preparation Products And Raw materials |
| Raw materials | Acetyl ketene |
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