4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE

CAS No.：17833-43-1

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4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE Basic information

Product Name:	4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
Synonyms:	4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE;4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE;4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOSIDE;4-METHYLUMBELLIFERYL A-D-GLUCOPYRANOSIDE;4-methyl-2-oxo-2H-chromen-7-yl-α-L-galactopyranoside;4-MethyluMbelliferyl α-D-Glucose;4-Methyl-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chroMen-2-one;4-MethyluMbellifery -α-D-glucoside
CAS:	17833-43-1
MF:	C16H18O8
MW:	338.31
EINECS:	241-794-0
Product Categories:	substrate;Substrates;13C & 2H Sugars;Carbohydrates & Derivatives;Fluorescent Labels & Indicators;Labeling and Diagnostics Reagents
Mol File:	17833-43-1.mol

4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE Chemical Properties

Melting point	171-173 °C
Boiling point	626.9±55.0 °C(Predicted)
density	1.522±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 50 mg/mL, clear, colorless to faintly yellow
pka	12.73±0.70(Predicted)
form	White solid
color	White to Off-White
BRN	1690776
InChIKey	YUDPTGPSBJVHCN-JZYAIQKZSA-N
CAS DataBase Reference	17833-43-1(CAS DataBase Reference)

Safety Information

Safety Statements	22-24/25
WGK Germany	3
F	3-10-21
HS Code	2932209090

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE Usage And Synthesis

Description	4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase. 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.
Chemical Properties	white to off-white crystalline powder
Uses	4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate in the assay of a-glucosidase,it has been used in the study of Pompe disease.
Uses	4-Methylumbelliferyl α-D-glucopyranoside is used as a flurogenic substrate for the identification, characterization and kinetic analysis of α-D-glucosidase(s).
Purification Methods	Recrystallise 4-methylumbellifer-7-yl--D-glucopyranoside from hot H2O or EtOH. [Courtin-Duchateau & Veyrière Carbohydr Research 65 23, 29 1978, Beilstein 18 IV 443.]

4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE Preparation Products And Raw materials

Raw materials

4-Methylumbelliferyl2,3,4,6-tetra-O-acetyl-a-D-glucopyranoside

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