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| 2-Bromopropionic acid Basic information |
| 2-Bromopropionic acid Chemical Properties |
| Melting point | 25.7°C | | Boiling point | 203 °C (lit.) | | density | 1.7 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.475(lit.) | | Fp | 212 °F | | storage temp. | room temp | | form | Liquid After Melting | | pka | pK1: 2.971 (25°C) | | Specific Gravity | 1.7 | | color | Clear colorless to yellow | | Water Solubility | soluble | | BRN | 605451 | | NIST Chemistry Reference | 2-Bromopropanoic acid(598-72-1) | | EPA Substance Registry System | Propanoic acid, 2-bromo- (598-72-1) |
| 2-Bromopropionic acid Usage And Synthesis |
| Chemical Properties | clear colorless to yellowish liquid after melting. soluble in water, miscible with alcohol, ether, chloroform and benzene. | | Uses | It is employed as pharmaceutical and agrochemical intermediate. It is used as an alkylation agent for mercaptans and other sulfur containing compounds. | | Uses | 2-Bromopropionic Acid is a versatile reactant used in emulsion polymerization in the preparation of reversible addition-fragmentation chain transfer (RAFT) agent. | | Application | 2-bromopropionic acid is an organic synthesis intermediate, used in the production of herbicides quizalofop-ethyl, napropamide, fenthiaprop and fungicides metalaxyl, benalaxyl, procymidone, etc., used in the synthesis of pharmaceutical intermediates body alanine. | | Preparation | 2-Bromopropionic acid is obtained by bromination of propionic acid. Add propionic acid and phosphorus trichloride to the reaction kettle, keep the temperature at 80°C, slowly add bromine to the reaction solution dropwise, and heat up to 85°C after the addition of bromine, and raise the temperature to 100°C when the color of bromine disappears completely, it takes about 2~3h, and then the bromine and hydrobromic acid are recovered under reduced pressure, and then the finished product is obtained by distillation under reduced pressure. | | Synthesis Reference(s) | Tetrahedron Letters, 13, p. 4067, 1972 DOI: 10.1016/S0040-4039(01)94239-X |
| 2-Bromopropionic acid Preparation Products And Raw materials |
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