Other grades of this product :
| Troxerutin Basic information |
| Troxerutin Chemical Properties |
| Melting point | 181°C | | Boiling point | 1058.4±65.0 °C(Predicted) | | density | 1.65±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride. | | form | neat | | pka | 5.92±0.40(Predicted) | | color | Light Yellow to Yellow | | Merck | 14,9789 | | BRN | 4778232 | | InChIKey | KMPBUGGPUQOWMJ-NXPSPVSKSA-N | | CAS DataBase Reference | 7085-55-4(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | LK8331500 | | HS Code | 2938100000 |
| Troxerutin Usage And Synthesis |
| Chemical Properties | Yellow Powder | | Originator | Venoruton,Novartis Co | | Uses | Used in the treatment of venous disorders | | Uses | vasoprotectant | | Uses | Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time. | | Manufacturing Process | In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are
added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture
being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene
chlorohydrin being then introduced at 55°C for 10 min. When all the
chlorohydrin has been thus added the temperature is progressively raised to
75°C and maintained at this level for 2 hours. After cooling, in a nitrogen
atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric
acid. The solution is kept in an ice box for 24 hours and then filtered to
remove any impurities. At reduced pressure the solution is evaporated until
dry, the residue taken up in 3 litres of boning methanol which dissolves the
tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium
chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic
solution either by evaporation and refrigeration, or by evaporation
precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin
obtained is in the form of small very hygroscopic crystals which contain
alcohol of crystallization.These crystals are quickly shaken washed in a little
cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous
tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder
which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss
Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland | | Therapeutic Function | Topical venotonic |
| Troxerutin Preparation Products And Raw materials |
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