Hydantoin

CAS No.：461-72-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Hydantoin Basic information

Product Name:	Hydantoin
Synonyms:	2,4-IMIDAZOLIDINEDIONE;2,4-IMIDAZOLINEDIONE;2,4-(3H,5H)-IMIDAZOLEDIONE;Imidazolidine-2,4-dione;HYDANTOIN;GLYCOLYLUREA;2-hydroxy-2-imidazolin-4(or5)-on;imidazole-2,4-dione
CAS:	461-72-3
MF:	C3H4N2O2
MW:	100.08
EINECS:	207-313-3
Product Categories:	Building Blocks;Chemical Synthesis;Chemical Amines;Amines;Heterocycles;Heterocyclic Building Blocks;Pharmaceutical Intermediates;FINE Chemical & INTERMEDIATES;Building Blocks;Heterocyclic Building Blocks;Imidazolines/Imidazolidines;bc0001;461-72-3
Mol File:	461-72-3.mol

Hydantoin Chemical Properties

Melting point	218-220 °C (lit.)
Boiling point	187.47°C (rough estimate)
density	1.4457 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5110 (estimate)
storage temp.	Store below +30°C.
solubility	SLIGHTLY SOLUBLE
pka	pKa 9.1 (Uncertain)
form	Fine Powder
color	White to light yellow
Water Solubility	SLIGHTLY SOLUBLE
Merck	14,4760
BRN	110598
LogP	-1.69
CAS DataBase Reference	461-72-3(CAS DataBase Reference)
NIST Chemistry Reference	2,4-Imidazolidinedione(461-72-3)
EPA Substance Registry System	2,4-Imidazolidinedione (461-72-3)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-36/37/39-27-26
WGK Germany	3
RTECS	MT8210000
TSCA	Yes
HS Code	29332100

MSDS Information

Provider	Language
2,4-Imidazolinedione	English
ACROS	English
SigmaAldrich	English
ALFA	English

Hydantoin Usage And Synthesis

Chemical Properties	White Solid
Uses	Reactant for synthesis of: N-benzyl aplysinopsin analogs as anticancer agents1 D-glutamic acid based inhibitors2 Antidiabetic chromonyl-2,4-thiazolidinediones3 GSK-3β inhibitors with brain permeability4 Thiazolidinedione derivatives as 15-PGDH inhibitors5 Radio-sensitizing agents6
Uses	The product has been used as a substrate (at 40 °C and pH 9.0) to determine the D-hydantoinase activity in adzuki bean extract.

Hydantoin Preparation Products And Raw materials

Raw materials	Orotic acid-->SYNTHETIC RESIN-->N,N'-Diethylthiourea-->HYDANTOIC ACID-->Isopropyl alcohol-->Benzil
Preparation Products	Glycine-->L-Valine-->BANISTERINE MONOHYDRATE-->5-METHOXY-DL-TRYPTOPHAN-->(S)-2-AMINO-3-(6-METHOXY-1H-INDOL-3-YL)-PROPIONIC ACID-->S-α-cyano-3-phenoxy benzyl alcohol-->OROTIC ACID MONOHYDRATE-->PARABANIC ACID-->2-(4-FLUOROBENZOYL)ACETIC ACID

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