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| 2,4-Dichloro-5-fluoropyrimidine Basic information |
| Product Name: | 2,4-Dichloro-5-fluoropyrimidine | | Synonyms: | CHEMPACIFIC 37950;5-FLUORO-2,4-DICHLOROPYRIMIDINE;2,4-DICHLORO-5-FLUOROPYRIMIDINE;2,4-Dichloro-5-fluorouracil;5-Fluoro-2,4-dichloropyrimdine;2,6-DICHLORO-5-FLUORORACIL;2,4-Dichloro-5-Fluoropyrimidin;2,4-Dichloro-5-fluoropyrimidine99% | | CAS: | 2927-71-1 | | MF: | C4HCl2FN2 | | MW: | 166.97 | | EINECS: | 625-810-7 | | Product Categories: | Fluorine series;Aromatics;Bases & Related Reagents;Nucleotides;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Pyridines, Pyrimidines, Purines and Pteredines;Building Blocks;Fluorinated;Nucleotides and Nucleosides;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Pyrimidine Series;Heterocycles;pharmacetical;Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrimidine;bc0001 | | Mol File: | 2927-71-1.mol |
| 2,4-Dichloro-5-fluoropyrimidine Chemical Properties |
| Melting point | 37-41 °C (lit.) | | Boiling point | 80 °C / 16mmHg | | density | 1.605±0.06 g/cm3(Predicted) | | Fp | 223 °F | | storage temp. | Inert atmosphere,2-8°C | | form | Powder or Crystalline Powder or Low Melting Solid | | pka | -3.96±0.29(Predicted) | | color | White to pale brown | | Sensitive | Moisture Sensitive | | InChIKey | WHPFEQUEHBULBW-UHFFFAOYSA-N | | CAS DataBase Reference | 2927-71-1(CAS DataBase Reference) |
| 2,4-Dichloro-5-fluoropyrimidine Usage And Synthesis |
| Chemical Properties | 2,4-Dichloro-5-fluoropyrimidine is Yellow to Orange Crystalline Solid
| | Uses |
2,4-Dichloro-5-fluoropyrimidine is used in the synthesis of two glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors. It is used in the synthesis of two glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors.
| | Uses | 2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize: - 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
- A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
- 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
- 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
- 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
- 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.
| | Flammability and Explosibility | Notclassified |
| 2,4-Dichloro-5-fluoropyrimidine Preparation Products And Raw materials |
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