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| Butyrophenone Chemical Properties |
| Melting point | 11-13 °C(lit.) | | Boiling point | 228-230 °C(lit.) | | density | 1.021 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.520(lit.) | | Fp | 192 °F | | storage temp. | Store below +30°C. | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Liquid | | Specific Gravity | 0.988 | | color | Clear colorless to yellow | | Water Solubility | Insoluble in water. | | BRN | 508305 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | CAS DataBase Reference | 495-40-9(CAS DataBase Reference) | | NIST Chemistry Reference | 1-Butanone, 1-phenyl-(495-40-9) | | EPA Substance Registry System | 1-Butanone, 1-phenyl- (495-40-9) |
| Butyrophenone Usage And Synthesis |
| Description | Butyrophenone is a chemical compound with the formula C10H12O. Butyrophenone has been used to study the relationship between the electrolyte counter-ion concentration and the critical micelle concentration for several surfactants. It has been used to generate PhCO+ ions by 70 eV electron ionization. Some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics. They can interfere with neurotransmitter functions, usually blocking dopamine receptors, and induce behavioral, endocrine, motor-kinetic effects. Examples of butyrophenones include: Haloperidol, the most widely used classical antipsychotic drug in this class; Benperidol, the most potent commonly used antipsychotic ( 200 times more potent than chlorpromazine).
| | References | 1. https://en.wikipedia.org/wiki/Butyrophenone
2. http://www.rightdiagnosis.com/medical/butyrophenone.htm
3. http://www.sigmaaldrich.com/catalog/product/aldrich/124338?lang=en®ion=CA
| | Chemical Properties | colourless to yellow liquid | | Uses | Butyrophenone is used as intermediates of Liquid Crystals | | Uses | Intermediates of Liquid Crystals | | Synthesis Reference(s) | The Journal of Organic Chemistry, 61, p. 376, 1996 DOI: 10.1021/JO951500RTetrahedron Letters, 30, p. 6357, 1989 DOI: 10.1016/S0040-4039(01)93893-6 | | Biochem/physiol Actions | Butyrophenones constitutes neuroleptic drugs and interacts with the opiate receptor by inhibiting the stereospecific binding of 3H-naloxone. |
| Butyrophenone Preparation Products And Raw materials |
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