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| 4'-Hydroxy-3'-methoxypropiophenone Basic information |
| 4'-Hydroxy-3'-methoxypropiophenone Chemical Properties |
| Hazard Codes | T,N | | Risk Statements | 25-51/53 | | Safety Statements | 45-61 | | HS Code | 2914500090 |
| 4'-Hydroxy-3'-methoxypropiophenone Usage And Synthesis |
| Uses | 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone is a derivative of Guaiacol, a precursor to various flavorants, such as eugenol and vanillin. | | Preparation | Preparation by Fries rearrangement of 2-methoxyphenyl propionate, (b.p.20 140–143°)with aluminium chloride in nitrobenzene, first at 60–80° for 1 h, then at r.t. overnight, at 60° for 1 h or at 50° for 5 h (44%) ;with aluminium chloride (2 mol) in nitromethane at r.t. for 24 h (65%)with aluminium chloride in carbon disulfidewith titanium tetrachloride (2 mol) in nitromethane at r.t. for 24 h (62%)with stannic chloride (2 mol) in nitromethane at r.t. for 24 h (69%)with antimony pentachloride (2 mol) in nitromethane at r.t. for 24 h (28%) with formation of important tars. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 15, p. 227, 1950 DOI: 10.1021/jo01148a001 |
| 4'-Hydroxy-3'-methoxypropiophenone Preparation Products And Raw materials |
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