| Methyl 4-aminobenzoate Basic information |
| Product Name: | Methyl 4-aminobenzoate |
| Synonyms: | benzoicacid,4-amino-,methylester;Methyl aniline-4-carboxylate;Methyl ester of 4-aminobenzoic acid;Methyl ester of p-Aminobenzoic acid;methylaniline-4-carboxylate;p-(Methoxycarbonyl)aniline;p-Aminobenzoic acid methyl ester;p-aminobenzoicacidmethylester |
| CAS: | 619-45-4 |
| MF: | C8H9NO2 |
| MW: | 151.16 |
| EINECS: | 210-598-7 |
| Product Categories: | Aromatic Esters;C8 to C9;Carbonyl Compounds;Esters;Aromatic Amino Acids;Pyridines ,Halogenated Heterocycles;CARBOXYLICESTER;Peptide Synthesis;Unnatural Amino Acid Derivatives |
| Mol File: | 619-45-4.mol |
| Methyl 4-aminobenzoate Chemical Properties |
| Melting point | 110-111 °C (lit.) |
| Boiling point | 273.17°C (rough estimate) |
| density | 1.2023 (rough estimate) |
| refractive index | 1.5810 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 3.82g/l |
| form | Crystals or Crystalline Powder |
| pka | pK1:2.38(＋1) (25°C) |
| color | White to beige |
| Water Solubility | Soluble in alcohol and ether. Slightly soluble in water. |
| BRN | 775913 |
| InChIKey | LZXXNPOYQCLXRS-UHFFFAOYSA-N |
| CAS DataBase Reference | 619-45-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 4-amino-, methyl ester(619-45-4) |
| EPA Substance Registry System | Benzoic acid, 4-amino-, methyl ester (619-45-4) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 26-37/39-36/37/39 |
| WGK Germany | 3 |
| RTECS | DG2900000 |
| TSCA | Yes |
| HS Code | 29224995 |
| MSDS Information |
| Provider | Language |
|---|---|
| 4-Aminobenzoic acid methyl ester | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| Methyl 4-aminobenzoate Usage And Synthesis |
| Chemical Properties | white to beige crystals or crystalline powder |
| Uses | Methyl 4-aminobenzoate is used in the synthesis of guanidine alkaloids, (±)-martinelline and (±)-martinellic acid by a protic acid catalyzed hetero Diels-Alder coupling reaction with N-Cbz 2-pyrroline. It is also used in organic synthesis and acts as a dye intermediate. Further, it is used to prepare 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid methyl ester by reacting with 2-acetylamino-benzoic acid. |
| Uses | Methyl 4-aminobenzoate was used in the syntheses of guanidine alkaloids, (±)-martinelline and (±)-martinellic acid by a protic acid catalyzed hetero Diels-Alder coupling reaction with N-Cbz 2-pyrroline. |
| Synthesis Reference(s) | Synthetic Communications, 26, p. 973, 1996 DOI: 10.1080/00397919608003701Synthesis, p. 23, 1978 |
| General Description | The catalytic oxidation of methyl 4-aminobenzoate by hydrogen peroxide was studied. |
| Methyl 4-aminobenzoate Preparation Products And Raw materials |
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