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| 6(5H)-Phenanthridone Basic information |
| 6(5H)-Phenanthridone Chemical Properties |
| Melting point | 290-292 °C(lit.) | | Boiling point | 435 °C | | density | 1.230±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.27±0.20(Predicted) | | form | powder to crystal | | color | White to Light yellow to Light orange | | Water Solubility | Soluble in DMSO (5 mg/ml). Insoluble in water. | | λmax | 338nm(EtOH)(lit.) | | BRN | 140641 | | CAS DataBase Reference | 1015-89-0(CAS DataBase Reference) | | NIST Chemistry Reference | 6(5H)-phenanthridinone(1015-89-0) | | EPA Substance Registry System | 6-Phenanthridinone (1015-89-0) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | SG0370000 | | HS Code | 29337900 |
| 6(5H)-Phenanthridone Usage And Synthesis |
| Uses | 6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation. | | Uses | 6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor. | | Definition | ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity. | | Synthesis Reference(s) | Canadian Journal of Chemistry, 35, p. 180, 1957 DOI: 10.1139/v57-027Journal of the American Chemical Society, 79, p. 1245, 1957 DOI: 10.1021/ja01562a054 | | General Description | 6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated. |
| 6(5H)-Phenanthridone Preparation Products And Raw materials |
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