4-Fluorophenylacetonitrile

CAS No.：459-22-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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4-Fluorophenylacetonitrile Basic information

Product Name:	4-Fluorophenylacetonitrile
Synonyms:	P-FLUOROBENZYL CYANIDE;P-FLUOROPHENYLACETONITRILE;PARA-FLUOROBENZYL CYANIDE;p-Fluorobenzyl nitrile;4-Fluorophenylacetonitrile,4-Fluorobenzyl cyanide;4-Fluorophenylacetonitrile, 99% 25GR;The fluorine benzene acetonitrile;(p-fluorophenyl)-acetonitril
CAS:	459-22-3
MF:	C8H6FN
MW:	135.14
EINECS:	207-286-8
Product Categories:	Aromatic Nitriles;Nitrile;Fluorobenzene
Mol File:	459-22-3.mol

4-Fluorophenylacetonitrile Chemical Properties

Melting point	86°C
Boiling point	119-120 °C/18 mmHg (lit.)
density	1.126 g/mL at 25 °C (lit.)
refractive index	n20/D 1.5002(lit.)
Fp	227 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
color	Clear colorless to light yellow
BRN	1907764
Exposure limits	NIOSH: IDLH 25 mg/m3
InChIKey	JHQBLYITVCBGTO-UHFFFAOYSA-N
CAS DataBase Reference	459-22-3(CAS DataBase Reference)
NIST Chemistry Reference	4-Fluorophenylacetic acid nitrile(459-22-3)
EPA Substance Registry System	Benzeneacetonitrile, 4-fluoro- (459-22-3)

Safety Information

Hazard Codes	Xn,T,Xi
Risk Statements	20/21/22-36/37/38-20/21/22/36/37/38-20/20/22
Safety Statements	26-36-24/25-26/36/37/39
RIDADR	UN 3276 6.1/PG 3
WGK Germany	3
RTECS	AM0210000
Hazard Note	Toxic
TSCA	T
HazardClass	6.1
PackingGroup	III
HS Code	29269090

MSDS Information

Provider	Language
4-Fluorophenylacetonitrile	English
ACROS	English
SigmaAldrich	English
ALFA	English

4-Fluorophenylacetonitrile Usage And Synthesis

Chemical Properties	Clear light yellow liquid
General Description	4-Fluorophenylacetonitrile is starting reagent in the synthesis of 1-Alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives.
Biochem/physiol Actions	4-Fluorophenylacetonitrile undergoes biotransformation to 4-Fluorophenylacetic acid by marine fungi, Aspergillus sydowii Ce19.

4-Fluorophenylacetonitrile Preparation Products And Raw materials

Preparation Products

4-CYANO-4-(4-FLUOROPHENYL)CYCLOHEXANONE-->3-Fluorophenylacetonitrile-->1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE-->2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE-->Succinonitrile

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