Phenoxyacetic acid

Phenoxyacetic acid
  • CAS No.:122-59-8
Other grades of this product :
Phenoxyacetic acid Basic information
Product Name:Phenoxyacetic acid
Synonyms:Phenoxymethylpenicillin EP Impurity B;Phenoxymethylpenicillin Impurity 2(Phenoxymethylpenicillin EP Impurity B);2-cyclohexyloxyacetate;Glycolic acid phenyl ether;FEMA 2872;RARECHEM AL BO 0458;O-PHENYLGLYCOLIC ACID;PHENYLOXYL ACETIC ACID
CAS:122-59-8
MF:C8H8O3
MW:152.15
EINECS:204-556-7
Product Categories:Building Blocks;C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Agrochemical;intermediates
Mol File:122-59-8.mol
Phenoxyacetic acid Chemical Properties
Melting point 98-100 °C (lit.)
Boiling point 285 °C
density 1.2143 (rough estimate)
refractive index 1.4447 (estimate)
FEMA 2872 | PHENOXYACETIC ACID
Fp 165 °C
storage temp. Store below +30°C.
solubility ethanol: soluble10%, clear, colorless
form Granular Powder, Granules, or Prills
pka3.17(at 25℃)
color White
Water Solubility 0.1-0.5 g/100 mL at 17 ºC
Merck 14,7254
JECFA Number1026
BRN 907949
Stability:Stable. Substances to be avoided include strong bases, strong oxidizing agents. Combustible.
InChIKeyLCPDWSOZIOUXRV-UHFFFAOYSA-N
CAS DataBase Reference122-59-8(CAS DataBase Reference)
NIST Chemistry ReferenceAcetic acid, phenoxy-(122-59-8)
EPA Substance Registry SystemPhenoxyacetic acid (122-59-8)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36-37/39
RIDADR UN 3345 6.1/ PGIII
WGK Germany 3
RTECS AJ2230000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29189090
ToxicityLD50 orally in Rabbit: 1500 mg/kg LD50 dermal Rabbit > 5000 mg/kg
MSDS Information
ProviderLanguage
Glycolic acid phenyl ether English
SigmaAldrich English
ACROS English
ALFA English
Phenoxyacetic acid Usage And Synthesis
Chemical Propertiesoff-white powder
Chemical PropertiesPhenoxyacetic acid has a sour, sweet odor and a honey-like taste.
OccurrenceReported found in cocoa beans
UsesPhenoxyacetic acid is a flavoring ingredient.?Its photodegradation using titanium dioxide as photocatalyst has been studied. Selective separation of penicillin V from phenoxyacetic acid using liquid membranes consisting of 1,2-dichloroethane and Amberlite LA-2 as carrier has been studied.
UsesFungicide; keratin exfoliative (to relieve and to soften calluses, corns, and other hard skin surfaces; applied as plasters, pads or in liquids).
PreparationBy reacting phenol and monochloroacetic acid.
DefinitionChEBI: A monocarboxylic acid that is the O-phenyl derivative of glycolic acid. A metabolite of 2-phenoxyethanol, it is used in the manufacture of pharmaceuticals, pesticides, fungicides and dyes.
Synthesis Reference(s)Synthetic Communications, 16, p. 479, 1986 DOI: 10.1080/00397918608057726
General DescriptionLight tan powder or white solid.
Air & Water ReactionsSlightly soluble in water.
Reactivity ProfilePhenoxyacetic acid reacts exothermically with all bases, both organic (for example, the amines) and inorganic.
Health HazardACUTE/CHRONIC HAZARDS: Phenoxyacetic acid is a mild skin irritant.
Fire HazardFlash point data for Phenoxyacetic acid are not available; however Phenoxyacetic acid is probably combustible.
Purification MethodsCrystallise the acid from water or aqueous EtOH. [Beilstein 6 IV 634.]

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