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| 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Basic information |
| Product Name: | 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE | | Synonyms: | 5-BROMOCYTOSINE;6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE;TIMTEC-BB SBB000280;2(1H)-Pyrimidinone, 4-amino-5-bromo-;4-amino-5-bromo-2(1h)-pyrimidinon;4-Amino-5-bromo-2(1H)-pyrimidinone;4-Amino-5-bromo-2-hydroxypyrimidine;5-BROMOCYTOSINE CRYSTALLINE | | CAS: | 2240-25-7 | | MF: | C4H4BrN3O | | MW: | 190 | | EINECS: | 218-806-8 | | Product Categories: | | Mol File: | 2240-25-7.mol |
| 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Chemical Properties |
| Melting point | 240-243 °C (dec.) (lit.) | | density | 1.7513 (rough estimate) | | refractive index | 1.6520 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in formic acid (50 mg/ml). | | form | Solid | | pka | 7.34±0.10(Predicted) | | color | White to yellow | | BRN | 127286 | | NIST Chemistry Reference | 5-Bromocytosine(2240-25-7) |
| 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Usage And Synthesis |
| Chemical Properties | LIGHT YELLOW AMORPHOUS POWDER | | Uses | 4-Amino-5-bromo-2-hydroxypyrimidine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions. | | Uses | 5-Bromocytosine was used in the synthesis of five cross-link products- C[5-N6]A, C[5-2]A, C[5-8]A, A[2-5]C, and A[8-5]C, under both aerobic and anaerobic conditions. | | General Description | 5-Bromocytosine derivative (β isomer) is a potent anti-HIV agent. | | Purification Methods | 5-Bromocytosine is recrystallised from H2O or 50% aqueous EtOH. Alternatively, dissolve ca 3g in conc HCl (10mL) and evaporate to dryness. Dissolve the residual hydrochloride in the minimum volume of warm H2O and make faintly alkaline with aqueous NH3. Collect the crystals and dry them in a vacuum at 100o. [Hilbdert & Jensen J Am Chem Soc 56 134 1934, Beilstein 25 III/IV 3689.] |
| 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Preparation Products And Raw materials |
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