| 2-Fluorobenzoic acid Basic information |
| Product Name: | 2-Fluorobenzoic acid |
| Synonyms: | NSC 10319;Adjacent acid;2-Fluorobenzoic acid≥ 99% (HPLC);OFBA;O-FLUOROBENZOIC ACID;RARECHEM AL BO 0015;2-FLUOROBENZOIC ACID;2-Fluorobenzoicaid |
| CAS: | 445-29-4 |
| MF: | C7H5FO2 |
| MW: | 140.11 |
| EINECS: | 207-158-1 |
| Product Categories: | Aryl Fluorinated Building Blocks;Building Blocks;organofluorine compounds;Aromatics;Intermediates & Fine Chemicals;Carbonyl Compounds;FINE Chemical & INTERMEDIATES;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Fluorobenzene;C7;Carbonyl Compounds;Carboxylic Acids;Pharmaceuticals;carboxylic acid| alkyl Fluorine;Carboxylic Acids;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;bc0001 |
| Mol File: | 445-29-4.mol |
| 2-Fluorobenzoic acid Chemical Properties |
| Melting point | 122-125 °C (lit.) |
| Boiling point | 114 °C |
| density | 1,46 g/cm3 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 7.2g/l |
| form | Crystalline Powder or Needles |
| pka | 3.27(at 25℃) |
| color | White to light yellow |
| Water Solubility | Slightly soluble in water. |
| BRN | 971265 |
| InChIKey | NSTREUWFTAOOKS-UHFFFAOYSA-N |
| CAS DataBase Reference | 445-29-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 2-fluoro-(445-29-4) |
| EPA Substance Registry System | Benzoic acid, 2-fluoro- (445-29-4) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 37/38-36/37/38 |
| Safety Statements | 22-26-28-24/25-37/39-36 |
| WGK Germany | 3 |
| RTECS | DH0250000 |
| TSCA | T |
| HazardClass | IRRITANT |
| HS Code | 29163900 |
| MSDS Information |
| Provider | Language |
|---|---|
| 2-Fluorobenzoic acid | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 2-Fluorobenzoic acid Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder. soluble in organic solvents such as benzene, toluene, ketone and ether.The corresponding 2-fluorobenzoyl chloride can be obtained by reacting 2-fluorobenzoic acid with an acid chloride agent such as SOCl2, PCl3, etc. |
| Uses | 2-Fluorobenzoic acid is an intermediate of the fungicide tritriazole and meclofenamic acid. |
| Uses | 2-Fluorobenzoic acid may be employed in the preparation of zaragozic acid A analogs. It is also used as an organic chemical synthesis intermediate. |
| Preparation | The preparation of 2-fluorobenzoic acid is based on anthranilic acid as raw material, adding anhydrous hydrogen fluoride and sodium nitrite in methoxyethyl methyl ether solvent for diazotization, refluxing for 3 hours, and post-processing to obtain the finished product. |
| Definition | ChEBI: 2-fluorobenzoic acid is a 2-halobenzoic acid that is benzoic acid carrying a fluoro substituent at position 2. It is a fluorobenzoic acid and a 2-halobenzoic acid. It is a conjugate acid of a 2-fluorobenzoate. |
| Purification Methods | Crystallise the acid from 50% aqueous EtOH, dilute HCl or *C6H6, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333. 9 III 1324, 9 IV 950.] |
| 2-Fluorobenzoic acid Preparation Products And Raw materials |
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