5-Methoxysalicylic acid

5-Methoxysalicylic acid
  • CAS No.:2612-02-4

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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5-Methoxysalicylic acid Basic information
Product Name:5-Methoxysalicylic acid
Synonyms:RARECHEM AL BO 0993;LABOTEST-BB LT00847979;acid5-methoxysalicylic;2-Hydroxy-5-Methoxybenzoic;Benzoic acid, 2-hydroxy-5-methoxy-;2-HYDROXY-5-METHOXYBENZOIC ACID;6-HYDROXY-3-ANISIC ACID;5-O-METHYL GENTISIC ACID
CAS:2612-02-4
MF:C8H8O4
MW:168.15
EINECS:220-037-8
Product Categories:Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Acids and Derivatives;Alcohols and Derivatives;Organic acids;Building Blocks;C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
Mol File:2612-02-4.mol
5-Methoxysalicylic acid Chemical Properties
Melting point 141-143 °C(lit.)
Boiling point 217.07°C (rough estimate)
density 1.1816 (rough estimate)
refractive index 1.4611 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka3.01±0.10(Predicted)
form Fine Crystalline Powder
color Beige
Water Solubility 1.7 g/L (10 ºC)
BRN 2209647
InChIKeyIZZIWIAOVZOBLF-UHFFFAOYSA-N
CAS DataBase Reference2612-02-4(CAS DataBase Reference)
EPA Substance Registry SystemBenzoic acid, 2-hydroxy-5-methoxy- (2612-02-4)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 26-36
WGK Germany 3
TSCA Yes
HS Code 29189900
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
5-Methoxysalicylic acid Usage And Synthesis
Description5-Methoxysalicylic acid is a chemical compound belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. It is a component of castoreum, the exudate from the castor sacs of the mature beaver.A mixture of 5-methoxysalicylic acid and spermine can be used as a matrix for oligonucleotides analysis in MALDI mass spectrometry.It is an isomer of vanillic acid.2-Hydroxy-5-methoxybenzoic acid is matrix additive which enhances the electrical conductivity of the matrix crystal during matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).
Chemical Propertiesbeige fine crystalline powder
Uses5-Methoxysalicylic acid was used to evaluate MALDI matrix/solvent combinations for intact spore mass spectrometry of Fusarium species.
Uses2-Hydroxy-5-methoxybenzoic acid was used to evaluate MALDI matrix/solvent combinations for intact spore mass spectrometry of Fusarium species.
DefinitionChEBI:5-methoxysalicylic acid is a methoxysalicylic acid that is salicylic acid which is carrying a methoxy group at position 5. It has a role as a bacterial metabolite and a human urinary metabolite.
Synthesis Reference(s)Journal of the American Chemical Society, 72, p. 2301, 1950 DOI: 10.1021/ja01161a530
General Description2-Hydroxy-5-methoxybenzoic acid is matrix additive which enhances the electrical conductivity of the matrix crystal during matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).
5-Methoxysalicylic acid Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Hydrochloric acid-->Sodium bicarbonate-->Carbon tetrachloride-->Copper-->Activated carbon-->4-Methoxyphenol
Preparation ProductsGENTISIN

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